ID   E9PS48_HUMAN            Unreviewed;       161 AA.
AC   E9PS48;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 45.
DE   SubName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial {ECO:0000313|Ensembl:ENSP00000432099};
GN   Name=NDUFS3 {ECO:0000313|Ensembl:ENSP00000432099};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000432099, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000432099, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000432099}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AC090559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PS48; -.
DR   jPOST; E9PS48; -.
DR   MaxQB; E9PS48; -.
DR   PeptideAtlas; E9PS48; -.
DR   PRIDE; E9PS48; -.
DR   Ensembl; ENST00000528192; ENSP00000432099; ENSG00000213619.
DR   UCSC; uc058bgk.1; human.
DR   EuPathDB; HostDB:ENSG00000213619.9; -.
DR   HGNC; HGNC:7710; NDUFS3.
DR   OpenTargets; ENSG00000213619; -.
DR   eggNOG; KOG1713; Eukaryota.
DR   eggNOG; COG0852; LUCA.
DR   GeneTree; ENSGT00390000017480; -.
DR   ChiTaRS; NDUFS3; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000213619; Expressed in 234 organ(s), highest expression level in muscle of leg.
DR   ExpressionAtlas; E9PS48; baseline and differential.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   Gene3D; 3.30.460.80; -; 1.
DR   InterPro; IPR037232; NADH_quin_OxRdtase_su_C/D-like.
DR   InterPro; IPR001268; NADH_UbQ_OxRdtase_30kDa_su.
DR   Pfam; PF00329; Complex1_30kDa; 1.
DR   SUPFAM; SSF143243; SSF143243; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E9PS48,
KW   ECO:0000213|MaxQB:E9PS48, ECO:0000213|PeptideAtlas:E9PS48};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    161       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245294.
FT   DOMAIN       87    127       Complex1_30kDa.
FT                                {ECO:0000259|Pfam:PF00329}.
SQ   SEQUENCE   161 AA;  17507 MW;  4D7EAF7A01E8DFFE CRC64;
     MAAAAVARLW WRGILGASAL TRGTGRPSVL LLPVRRESAG ADTRPTVRPR NDVAHKQLSA
     FGEYVAEILP KYVQQVQVSC FNELEVCIHP DGVIPVLTFL RDHTNAQFKS LVDLTAVDVP
     TRQNRFETES CSVARLECSG MILAHCNLRL PGSSDSPASA P
//