ID   E9PRX9_HUMAN            Unreviewed;       766 AA.
AC   E9PRX9;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 2.
DT   16-JAN-2019, entry version 57.
DE   SubName: Full=Kin of IRRE-like protein 3 {ECO:0000313|Ensembl:ENSP00000434081};
GN   Name=KIRREL3 {ECO:0000313|Ensembl:ENSP00000434081};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434081, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000434081, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000434081}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP000741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP000806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP002832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001288026.1; NM_001301097.1.
DR   RefSeq; XP_011541335.1; XM_011543033.1.
DR   UniGene; Hs.376015; -.
DR   ProteinModelPortal; E9PRX9; -.
DR   jPOST; E9PRX9; -.
DR   PeptideAtlas; E9PRX9; -.
DR   PRIDE; E9PRX9; -.
DR   Ensembl; ENST00000529097; ENSP00000434081; ENSG00000149571.
DR   GeneID; 84623; -.
DR   UCSC; uc001qeb.4; human.
DR   CTD; 84623; -.
DR   EuPathDB; HostDB:ENSG00000149571.10; -.
DR   HGNC; HGNC:23204; KIRREL3.
DR   OpenTargets; ENSG00000149571; -.
DR   eggNOG; KOG3510; Eukaryota.
DR   eggNOG; ENOG410XPX0; LUCA.
DR   GeneTree; ENSGT00940000157126; -.
DR   OrthoDB; 269917at2759; -.
DR   ChiTaRS; KIRREL3; human.
DR   GenomeRNAi; 84623; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149571; Expressed in 122 organ(s), highest expression level in brain.
DR   ExpressionAtlas; E9PRX9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 5.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF13895; Ig_2; 1.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 3.
DR   SUPFAM; SSF48726; SSF48726; 5.
DR   PROSITE; PS50835; IG_LIKE; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E9PRX9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    766       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242958.
FT   TRANSMEM    522    546       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       48    142       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      147    243       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      249    330       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      335    415       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      419    515       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   766 AA;  84136 MW;  CD8B4FEE20BD6CE5 CRC64;
     MKPFQLDLLF VCFFLFSQEL GLQKRGCCLV LGYMAKDKFR RMNEGQVYSF SQQPQDQVVV
     SGQPVTLLCA IPEYDGFVLW IKDGLALGVG RDLSSYPQYL VVGNHLSGEH HLKILRAELQ
     DDAVYECQAI QAAIRSRPAR LTVLVPPDDP VILGGPVISL RAGDPLNLTC HADNAKPAAS
     IIWLRKGEVI NGATYSKTLL RDGKRESIVS TLFISPGDVE NGQSIVCRAT NKAIPGGKET
     SVTIDIQHPP LVNLSVEPQP VLEDNVVTFH CSAKANPAVT QYRWAKRGQI IKEASGEVYR
     TTVDYTYFSE PVSCEVTNAL GSTNLSRTVD VYFGPRMTTE PQSLLVDLGS DAIFSCAWTG
     NPSLTIVWMK RGSGVVLSNE KTLTLKSVRQ EDAGKYVCRA VVPRVGAGER EVTLTVNGPP
     IISSTQTQHA LHGEKGQIKC FIRSTPPPDR IAWSWKENVL ESGTSGRYTV ETISTEEGVI
     STLTISNIVR ADFQTIYNCT AWNSFGSDTE IIRLKEQESV PMAVIIGVAV GAGVAFLVLM
     ATIVAFCCAR SQRNLKGVVS AKNDIRVEIV HKEPASGREG EEHSTIKQLM MDRGEFQQDS
     VLKQLEVLKE EEKEFQNLKD PTNGYYSVNT FKEHHSTPTI SLSSCQPDLR PAGKQRVPTG
     MSFTNIYSTL SGQGRLYDYG QRFVLGMGSS SIELCEREFQ RGSLSDSSSF LDTQCDSSVS
     SSGKQDGYVQ FDKASKASAS SSHHSQSSSQ NSDPSRPLQR RMQTHV
//