ID E9PRW4_HUMAN Unreviewed; 593 AA. AC E9PRW4; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 2. DT 16-JAN-2019, entry version 60. DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056}; GN Name=SLCO2B1 {ECO:0000313|Ensembl:ENSP00000434112}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434112, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000434112, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000434112} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000213|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [4] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000256|RuleBase:RU362056}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU362056}. CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) CC family. {ECO:0000256|RuleBase:RU362056}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|RuleBase:RU362056}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AP001972; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF455415; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9PRW4; -. DR jPOST; E9PRW4; -. DR PeptideAtlas; E9PRW4; -. DR PRIDE; E9PRW4; -. DR Ensembl; ENST00000532236; ENSP00000434112; ENSG00000137491. DR UCSC; uc010rrs.3; human. DR EuPathDB; HostDB:ENSG00000137491.14; -. DR HGNC; HGNC:10962; SLCO2B1. DR OpenTargets; ENSG00000137491; -. DR eggNOG; KOG3626; Eukaryota. DR eggNOG; ENOG410XRSF; LUCA. DR GeneTree; ENSGT00940000153999; -. DR ChiTaRS; SLCO2B1; human. DR Proteomes; UP000005640; Chromosome 11. DR Bgee; ENSG00000137491; Expressed in 204 organ(s), highest expression level in right lobe of liver. DR ExpressionAtlas; E9PRW4; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005215; F:transporter activity; IEA:InterPro. DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW. DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro. DR InterPro; IPR002350; Kazal_dom. DR InterPro; IPR036259; MFS_trans_sf. DR InterPro; IPR004156; OATP. DR PANTHER; PTHR11388; PTHR11388; 1. DR Pfam; PF03137; OATP; 1. DR SUPFAM; SSF103473; SSF103473; 1. DR TIGRFAMs; TIGR00805; oat; 1. DR PROSITE; PS51465; KAZAL_2; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Ion transport {ECO:0000256|RuleBase:RU362056}; KW Membrane {ECO:0000256|RuleBase:RU362056}; KW Proteomics identification {ECO:0000213|MaxQB:E9PRW4, KW ECO:0000213|PeptideAtlas:E9PRW4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|RuleBase:RU362056}; KW Transmembrane helix {ECO:0000256|RuleBase:RU362056}; KW Transport {ECO:0000256|RuleBase:RU362056}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 593 Solute carrier organic anion transporter FT family member. {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003244197. FT TRANSMEM 72 97 Helical. {ECO:0000256|RuleBase:RU362056}. FT TRANSMEM 109 137 Helical. {ECO:0000256|RuleBase:RU362056}. FT TRANSMEM 157 181 Helical. {ECO:0000256|RuleBase:RU362056}. FT TRANSMEM 256 278 Helical. {ECO:0000256|RuleBase:RU362056}. FT TRANSMEM 290 316 Helical. {ECO:0000256|RuleBase:RU362056}. FT TRANSMEM 328 348 Helical. {ECO:0000256|RuleBase:RU362056}. FT TRANSMEM 444 471 Helical. {ECO:0000256|RuleBase:RU362056}. FT TRANSMEM 492 515 Helical. {ECO:0000256|RuleBase:RU362056}. FT TRANSMEM 535 557 Helical. {ECO:0000256|RuleBase:RU362056}. FT DOMAIN 367 427 Kazal-like. FT {ECO:0000259|PROSITE:PS51465}. SQ SEQUENCE 593 AA; 64217 MW; B10BD9DD7D3B7267 CRC64; MIGYGAILVA LAGLLMTLPH FISEPYRYDN TSPEDMPQDF KASLCLPTTS APASAPSNGN CSSYTETQHL SVVGIMFVAQ TLLGVGGVPI QPFGISYIDD FAHNSNSPLY LGILFAVTMM GPGLAFGLGS LMLRLYVDIN QMPEGGISLT IKDPRWVGAW WLGFLIAAGA VALAAIPYFF FPKEMPKEKR ELQFRRKVLA VTDSPARKGK DSPSKQSPGE STKKQDGLVQ IAPNLTVIQF IKVFPRVLLQ TLRHPIFLLV VLSQVCLSSM AAGMATFLPK FLERQFSITA SYANLLIGCL SFPSVIVGIV VGGVLVKRLH LGPVGCGALC LLGMLLCLFF SLPLFFIGCS SHQIAGITHQ TSAHPGLELS PSCMEACSCP LDGFNPVCDP STRVEYITPC HAGCSSWVVQ DALDNSQVFY TNCSCVVEGN PVLAGSCDST CSHLVVPFLL LVSLGSALAC LTHTPSFMLI LRGVKKEDKT LAVGIQFMFL RILAWMPSPV IHGSAIDTTC VHWALSCGRR AVCRYYNNDL LRNRFIGLQF FFKTGSVICF ALVLAVLRQQ DKEARTKESR SSPAVEQQLL VSGPGKKPED SRV //