ID   E9PRW2_HUMAN            Unreviewed;       248 AA.
AC   E9PRW2;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 56.
DE   SubName: Full=Receptor-type tyrosine-protein phosphatase kappa {ECO:0000313|Ensembl:ENSP00000434116};
GN   Name=PTPRK {ECO:0000313|Ensembl:ENSP00000434116};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434116, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000434116, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000434116}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000486448}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; AC212491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL035465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL035470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL035594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL357621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL451073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL590006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; E9PRW2; -.
DR   jPOST; E9PRW2; -.
DR   MaxQB; E9PRW2; -.
DR   PRIDE; E9PRW2; -.
DR   Ensembl; ENST00000525459; ENSP00000434116; ENSG00000152894.
DR   Ensembl; ENST00000628472; ENSP00000486448; ENSG00000273993.
DR   UCSC; uc063rgo.1; human.
DR   EuPathDB; HostDB:ENSG00000152894.14; -.
DR   HGNC; HGNC:9674; PTPRK.
DR   OpenTargets; ENSG00000152894; -.
DR   eggNOG; KOG4228; Eukaryota.
DR   eggNOG; COG5599; LUCA.
DR   GeneTree; ENSGT00940000156249; -.
DR   ChiTaRS; PTPRK; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000152894; Expressed in 232 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; E9PRW2; baseline and differential.
DR   GO; GO:0030054; C:cell junction; IDA:HPA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   CDD; cd06263; MAM; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000998; MAM_dom.
DR   Pfam; PF00629; MAM; 1.
DR   PRINTS; PR00020; MAMDOMAIN.
DR   SMART; SM00137; MAM; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS00740; MAM_1; 1.
DR   PROSITE; PS50060; MAM_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:E9PRW2,
KW   ECO:0000213|MaxQB:E9PRW2, ECO:0000213|PeptideAtlas:E9PRW2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    248       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014571010.
FT   TRANSMEM    164    186       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       34    168       MAM. {ECO:0000259|PROSITE:PS50060}.
SQ   SEQUENCE   248 AA;  27691 MW;  D4C62AEEE98ACDD6 CRC64;
     MDTTAAAALP AFVALLLLSP WPLLGSAQGQ FSAGGCTFDD GPGACDYHQD LYDDFEWVHV
     SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK ARLQLPTMKE NDTHCIDFSY LLYSQKGLNP
     GTLNILVRVN KGPLANPIWN VTGFTGRDWL RAELAVSTFW PNEYQVIICT FLVYVLMSSV
     LTICVIHRCK YASHGNERLP SCLPHPHYWG SVIHRYTYAS HGNERLPLFL PHPVDEEVFG
     DIGTKPSN
//