ID   E9PRU1_HUMAN            Unreviewed;       436 AA.
AC   E9PRU1;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 67.
DE   SubName: Full=EGF-containing fibulin-like extracellular matrix protein 2 {ECO:0000313|Ensembl:ENSP00000434151};
GN   Name=EFEMP2 {ECO:0000313|Ensembl:ENSP00000434151};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434151, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000434151, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000434151}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AP001201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PRU1; -.
DR   jPOST; E9PRU1; -.
DR   PeptideAtlas; E9PRU1; -.
DR   PRIDE; E9PRU1; -.
DR   Ensembl; ENST00000528176; ENSP00000434151; ENSG00000172638.
DR   UCSC; uc058dqr.1; human.
DR   EuPathDB; HostDB:ENSG00000172638.12; -.
DR   HGNC; HGNC:3219; EFEMP2.
DR   OpenTargets; ENSG00000172638; -.
DR   GeneTree; ENSGT00940000159437; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000172638; Expressed in 230 organ(s), highest expression level in tendon of biceps brachii.
DR   ExpressionAtlas; E9PRU1; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048251; P:elastic fiber assembly; IEA:InterPro.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR026824; Efemp2.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR037287; Fibulin_3/4/5.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   PANTHER; PTHR44074; PTHR44074; 1.
DR   PANTHER; PTHR44074:SF3; PTHR44074:SF3; 1.
DR   Pfam; PF12662; cEGF; 2.
DR   Pfam; PF07645; EGF_CA; 3.
DR   SMART; SM00181; EGF; 5.
DR   SMART; SM00179; EGF_CA; 6.
DR   SUPFAM; SSF57184; SSF57184; 2.
DR   PROSITE; PS00010; ASX_HYDROXYL; 4.
DR   PROSITE; PS01186; EGF_2; 3.
DR   PROSITE; PS50026; EGF_3; 4.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00909960};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PRU1,
KW   ECO:0000213|PeptideAtlas:E9PRU1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00594563};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    436       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245283.
FT   DOMAIN      123    163       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      164    202       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      203    238       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      243    282       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DISULFID    207    217       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   436 AA;  48192 MW;  93BF749EB2115F38 CRC64;
     MLPCASCLPG SLLLWALLLL LLGSASPQDS EEPDSYTECT DGYEWDPDSQ HCRDVNECLT
     IPEACKGEMK CINHYGGYLC LPRSAAVIND LHGEGPPPPV PPAQHPNPCP PGYEPDDQDS
     CVDVDECAQA LHDCRPSQDC HNLPGSYQCT CPDGYRKIGP ECVDIDECRY RYCQHRCVNL
     PGSFRCQCEP GFQLGPNNRS CVDVNECDMG APCEQRCFNS YGTFLCRCHQ GYELHRDGFS
     CSDIDECSYS SYLCQYRCIN EPGRFSCHCP QGYQLLATRL CQDIDECESG AHQCSEAQTC
     VNFHGGYRCV DTNRCVEPYI QVSENRCLCP ASNPLCREQP SSIVHRYMTI TSERSVPADV
     FQIQATSVYP GAYNAFQIRA GNSQGDFYIR AQGPPLTGAG SSAPRASVTP RGEEVTRRAD
     SRPRPRDLDL AGLQGS
//