ID   E9PRQ8_HUMAN            Unreviewed;       183 AA.
AC   E9PRQ8;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 60.
DE   SubName: Full=EGF-containing fibulin-like extracellular matrix protein 2 {ECO:0000313|Ensembl:ENSP00000435963};
DE   Flags: Fragment;
GN   Name=EFEMP2 {ECO:0000313|Ensembl:ENSP00000435963};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000435963, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000435963, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000435963}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AP001201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PRQ8; -.
DR   jPOST; E9PRQ8; -.
DR   PeptideAtlas; E9PRQ8; -.
DR   PRIDE; E9PRQ8; -.
DR   Ensembl; ENST00000527378; ENSP00000435963; ENSG00000172638.
DR   UCSC; uc058drc.1; human.
DR   EuPathDB; HostDB:ENSG00000172638.12; -.
DR   HGNC; HGNC:3219; EFEMP2.
DR   OpenTargets; ENSG00000172638; -.
DR   eggNOG; ENOG410IR6U; Eukaryota.
DR   eggNOG; ENOG410ZNNG; LUCA.
DR   GeneTree; ENSGT00940000159437; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000172638; Expressed in 230 organ(s), highest expression level in tendon of biceps brachii.
DR   ExpressionAtlas; E9PRQ8; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048251; P:elastic fiber assembly; IEA:InterPro.
DR   InterPro; IPR026824; Efemp2.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR037287; Fibulin_3/4/5.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   PANTHER; PTHR44074; PTHR44074; 1.
DR   PANTHER; PTHR44074:SF3; PTHR44074:SF3; 1.
DR   Pfam; PF07645; EGF_CA; 2.
DR   SMART; SM00181; EGF; 1.
DR   SMART; SM00179; EGF_CA; 3.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS01187; EGF_CA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00602928};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PRQ8,
KW   ECO:0000213|PeptideAtlas:E9PRQ8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00594563};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    183       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003244191.
FT   DOMAIN      123    163       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   NON_TER     183    183       {ECO:0000313|Ensembl:ENSP00000435963}.
SQ   SEQUENCE   183 AA;  20095 MW;  661C7B0967499D54 CRC64;
     MLPCASCLPG SLLLWALLLL LLGSASPQDS EEPDSYTECT DGYEWDPDSQ HCRDVNECLT
     IPEACKGEMK CINHYGGYLC LPRSAAVIND LHGEGPPPPV PPAQHPNPCP PGYEPDDQDS
     CVDVDECAQA LHDCRPSQDC HNLPGSYQCT CPDGYRKIGP ECVDIDECRY RYCQHRCVNL
     PGS
//