ID   E9PR86_HUMAN            Unreviewed;       335 AA.
AC   E9PR86;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 57.
DE   SubName: Full=Low-density lipoprotein receptor class A domain-containing protein 3 {ECO:0000313|Ensembl:ENSP00000434313};
GN   Name=LDLRAD3 {ECO:0000313|Ensembl:ENSP00000434313};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434313, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000434313, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000434313}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR   EMBL; AC026269; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC087277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC129502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL136146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PR86; -.
DR   jPOST; E9PR86; -.
DR   PeptideAtlas; E9PR86; -.
DR   PRIDE; E9PR86; -.
DR   Ensembl; ENST00000524419; ENSP00000434313; ENSG00000179241.
DR   UCSC; uc058akj.1; human.
DR   EuPathDB; HostDB:ENSG00000179241.12; -.
DR   HGNC; HGNC:27046; LDLRAD3.
DR   OpenTargets; ENSG00000179241; -.
DR   GeneTree; ENSGT00940000160574; -.
DR   ChiTaRS; LDLRAD3; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000179241; Expressed in 193 organ(s), highest expression level in testis.
DR   ExpressionAtlas; E9PR86; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00112; LDLa; 2.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   Pfam; PF00057; Ldl_recept_a; 2.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00192; LDLa; 2.
DR   SUPFAM; SSF57424; SSF57424; 2.
DR   PROSITE; PS01209; LDLRA_1; 2.
DR   PROSITE; PS50068; LDLRA_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124,
KW   ECO:0000256|SAAS:SAAS01050632}; Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E9PR86};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    335       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242921.
FT   TRANSMEM    162    184       Helical. {ECO:0000256|SAM:Phobius}.
FT   DISULFID     42     57       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID     64     76       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID     71     89       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID     83     98       {ECO:0000256|PROSITE-ProRule:PRU00124}.
SQ   SEQUENCE   335 AA;  36024 MW;  93E01F971D374A5F CRC64;
     MWLLGPLCLL LSSAAAKAKS KCGPTFFPCA SGIHCIIGRF RCNGFEDCPD GSDEENCTAN
     PLLCSTARYH CKNGLCIDKS FICDGQNNCQ DNSDEESCES SQVSLLLPRL ECSGTISAHC
     KLRLPGSRHS PASASRVAGT TEPGSGQVFV TSENQLVYYP SITYAIIGSS VIFVLVVALL
     ALVLHHQRKR NNLMTLPVHR LQHPVLLSRL VVLDHPHHCN VTYNVNNGIQ YVASQAEQNA
     SEVGSPPSYS EALLDQRPAW YDLPPPPYSS DTESLNQADL PPYRSRSGSA NSASSQAASS
     LLSVEDTSHS PGQPGPQEGT AEPRDSEPSQ GTEEV
//