ID   E9PR43_HUMAN            Unreviewed;       391 AA.
AC   E9PR43;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   05-DEC-2018, entry version 49.
DE   SubName: Full=NADPH oxidase 4 {ECO:0000313|Ensembl:ENSP00000436093};
GN   Name=NOX4 {ECO:0000313|Ensembl:ENSP00000436093};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436093, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000436093, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000436093}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP001815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP002404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PR43; -.
DR   PeptideAtlas; E9PR43; -.
DR   PRIDE; E9PR43; -.
DR   Ensembl; ENST00000527626; ENSP00000436093; ENSG00000086991.
DR   UCSC; uc010rtu.3; human.
DR   EuPathDB; HostDB:ENSG00000086991.12; -.
DR   HGNC; HGNC:7891; NOX4.
DR   OpenTargets; ENSG00000086991; -.
DR   GeneTree; ENSGT00940000159621; -.
DR   ChiTaRS; NOX4; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000086991; Expressed in 127 organ(s), highest expression level in nephron tubule.
DR   ExpressionAtlas; E9PR43; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IDA:HPA.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.80; -; 2.
DR   InterPro; IPR000778; Cyt_b245_heavy_chain.
DR   InterPro; IPR013112; FAD-bd_8.
DR   InterPro; IPR017927; FAD-bd_FR_type.
DR   InterPro; IPR013121; Fe_red_NAD-bd_6.
DR   InterPro; IPR039261; FNR_nucleotide-bd.
DR   InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR   Pfam; PF08022; FAD_binding_8; 1.
DR   Pfam; PF08030; NAD_binding_6; 2.
DR   PRINTS; PR00466; GP91PHOX.
DR   SUPFAM; SSF52343; SSF52343; 1.
DR   SUPFAM; SSF63380; SSF63380; 1.
DR   PROSITE; PS51384; FAD_FR; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS01054190, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01054190,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01054190,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     15       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        16    391       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5012316571.
FT   TRANSMEM     25     47       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      138    253       FAD-binding FR-type.
FT                                {ECO:0000259|PROSITE:PS51384}.
SQ   SEQUENCE   391 AA;  45462 MW;  C24158A8830DAAA2 CRC64;
     MVVVLFLMIT ASTYAIRVSN YDIFWYTHNL FFVFYMLLTL HVSGGLLKYQ TNLDTHPPGC
     ISLNRTSSQN ISLPEYFSEH FHEPFPEGFS KPAEFTQHKF VKICMEEPRF QANFPQTWLW
     ISGPLCLYCA ERLYRYIRSN KPVTIISVMS HPSDVMEIRM VKENFKARPG QYITLHCPSV
     SALENHPFTL TMCPTETKAT FGVHLKIVGD WTERFRDLLL PPSSQDSEIL PFIQSRNYPK
     LYIDGPFGSP FEESLNYEVS LCVAGGIGVT PFASILNTLL DDWKPYKLRR LYFIWFWQEN
     RPDYVNIQLY LSQTDGIQKI IGEKYHALNS RLFIGRPRWK LLFDEIAKYN RGKTVGVFCC
     GPNSLSKTLH KLSNQNNSYG TRFEYNKESF S
//