ID   E9PQY1_HUMAN            Unreviewed;       225 AA.
AC   E9PQY1;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   05-DEC-2018, entry version 43.
DE   SubName: Full=Glutamate receptor 4 {ECO:0000313|Ensembl:ENSP00000432443};
DE   Flags: Fragment;
GN   Name=GRIA4 {ECO:0000313|Ensembl:ENSP00000432443};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000432443, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000432443, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000432443}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AP000641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF511108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PQY1; -.
DR   SMR; E9PQY1; -.
DR   PeptideAtlas; E9PQY1; -.
DR   PRIDE; E9PQY1; -.
DR   Ensembl; ENST00000531011; ENSP00000432443; ENSG00000152578.
DR   UCSC; uc058gyt.1; human.
DR   EuPathDB; HostDB:ENSG00000152578.12; -.
DR   HGNC; HGNC:4574; GRIA4.
DR   OpenTargets; ENSG00000152578; -.
DR   eggNOG; KOG1054; Eukaryota.
DR   eggNOG; ENOG410XPSH; LUCA.
DR   GeneTree; ENSGT00940000155677; -.
DR   ChiTaRS; GRIA4; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000152578; Expressed in 119 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; E9PQY1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00425515};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E9PQY1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00425515};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00425515}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    225       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245257.
FT   DOMAIN       40    163       ANF_receptor. {ECO:0000259|Pfam:PF01094}.
FT   NON_TER     225    225       {ECO:0000313|Ensembl:ENSP00000432443}.
SQ   SEQUENCE   225 AA;  25015 MW;  939EFEDE0AC5640C CRC64;
     MRIISRQIVL LFSGFWGLAM GAFPSSVQIG GLFIRNTDQE YTAFRLAIFL HNTSPNASEA
     PFNLVPHVDN IETANSFAVT NAFCSQYSRG VFAIFGLYDK RSVHTLTSFC SALHISLITP
     SFPTEGESQF VLQLRPSLRG ALLSLLDHYE WNCFVFLYDT DRGLVISTTP LASNCMPSSV
     VHSWLYVLYN KSINSITACL LGPSTELNVF NYLIADSNLN NGNYI
//