ID   E9PQU7_HUMAN            Unreviewed;       270 AA.
AC   E9PQU7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   SubName: Full=Layilin {ECO:0000313|Ensembl:ENSP00000434328};
GN   Name=LAYN {ECO:0000313|Ensembl:ENSP00000434328};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434328, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000434328, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000434328}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP002008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PQU7; -.
DR   jPOST; E9PQU7; -.
DR   MaxQB; E9PQU7; -.
DR   PeptideAtlas; E9PQU7; -.
DR   PRIDE; E9PQU7; -.
DR   Ensembl; ENST00000525126; ENSP00000434328; ENSG00000204381.
DR   UCSC; uc058heo.1; human.
DR   EuPathDB; HostDB:ENSG00000204381.11; -.
DR   HGNC; HGNC:29471; LAYN.
DR   OpenTargets; ENSG00000204381; -.
DR   eggNOG; ENOG410IS3Y; Eukaryota.
DR   eggNOG; ENOG410XR2Y; LUCA.
DR   GeneTree; ENSGT00390000001844; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000204381; Expressed in 176 organ(s), highest expression level in decidua.
DR   ExpressionAtlas; E9PQU7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PQU7,
KW   ECO:0000213|PeptideAtlas:E9PQU7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    270       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242943.
FT   TRANSMEM    233    259       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       45    185       C-type lectin.
FT                                {ECO:0000259|PROSITE:PS50041}.
SQ   SEQUENCE   270 AA;  30413 MW;  FCAEAB25F5CDE995 CRC64;
     MRPGTALQAV LLAVLLVGLR AATGRLLSAS DLDLRGGQPV CRGGTQRPCY KVIYFHDTSR
     RLNFEEAKEA CRRDGGQLVS IESEDEQKLI EKFIENLLPS DGDFWIGLRR REEKQSNSTA
     CQDLYAWTDG SISQFRNWYV DEPSCGSEVC VVMYHQPSAP AGIGGPYMFQ WNDDRCNMKN
     NFICKYSDEK PAVPSREAEG EETELTTPVL PEETQEEDAK KTFKESREAA LNLAYILIPS
     IPLLLLLVVT TVVCWVWICR KRQKTGAARP
//