ID   E9PQS3_HUMAN            Unreviewed;       158 AA.
AC   E9PQS3;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 51.
DE   SubName: Full=Amyloid-like protein 2 {ECO:0000313|Ensembl:ENSP00000434379};
DE   Flags: Fragment;
GN   Name=APLP2 {ECO:0000313|Ensembl:ENSP00000434379};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434379, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000434379, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000434379}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AP001183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP003041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PQS3; -.
DR   jPOST; E9PQS3; -.
DR   MaxQB; E9PQS3; -.
DR   PeptideAtlas; E9PQS3; -.
DR   PRIDE; E9PQS3; -.
DR   Ensembl; ENST00000533713; ENSP00000434379; ENSG00000084234.
DR   UCSC; uc058jcs.1; human.
DR   EuPathDB; HostDB:ENSG00000084234.16; -.
DR   HGNC; HGNC:598; APLP2.
DR   OpenTargets; ENSG00000084234; -.
DR   eggNOG; KOG3540; Eukaryota.
DR   eggNOG; ENOG410ZW2A; LUCA.
DR   GeneTree; ENSGT00940000158814; -.
DR   ChiTaRS; APLP2; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000084234; Expressed in 249 organ(s), highest expression level in pigmented layer of retina.
DR   ExpressionAtlas; E9PQS3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0008201; F:heparin binding; IEA:InterPro.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   Gene3D; 3.90.570.10; -; 1.
DR   InterPro; IPR036669; Amyloid_Cu-bd_sf.
DR   InterPro; IPR008155; Amyloid_glyco.
DR   InterPro; IPR008154; Amyloid_glyco_extra.
DR   InterPro; IPR015849; Amyloid_glyco_heparin-bd.
DR   InterPro; IPR036454; Amyloid_glyco_heparin-bd_sf.
DR   PANTHER; PTHR23103; PTHR23103; 1.
DR   Pfam; PF02177; APP_N; 1.
DR   SMART; SM00006; A4_EXTRA; 1.
DR   SUPFAM; SSF56491; SSF56491; 1.
DR   SUPFAM; SSF89811; SSF89811; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E9PQS3,
KW   ECO:0000213|MaxQB:E9PQS3, ECO:0000213|PeptideAtlas:E9PQS3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    158       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245447.
FT   DOMAIN       27    157       A4_EXTRA. {ECO:0000259|SMART:SM00006}.
FT   NON_TER     158    158       {ECO:0000313|Ensembl:ENSP00000434379}.
SQ   SEQUENCE   158 AA;  17823 MW;  18BD643413549E33 CRC64;
     MAATGTAAAA ATGRLLLLLL ALAANAGTGF AVAEPQIAMF CGKLNMHVNI QTGKWEPDPT
     GTKSCFETKE EVLQYCQEMY PELQITNVME ANQRVSIDNW CRRDKKQCKS RFVTPFKCLV
     GEFVSDVLLV PEKCQFFHKE RMEVCENHQH WHTVVKEV
//