ID   E9PQN4_HUMAN            Unreviewed;       604 AA.
AC   E9PQN4;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 57.
DE   SubName: Full=Complement receptor type 1 {ECO:0000313|Ensembl:ENSP00000436139};
GN   Name=CR1 {ECO:0000313|Ensembl:ENSP00000436139};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436139, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000436139, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000436139}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR   EMBL; AL137789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL691452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PQN4; -.
DR   jPOST; E9PQN4; -.
DR   PeptideAtlas; E9PQN4; -.
DR   PRIDE; E9PQN4; -.
DR   Ensembl; ENST00000534202; ENSP00000436139; ENSG00000203710.
DR   UCSC; uc057ozt.1; human.
DR   EuPathDB; HostDB:ENSG00000203710.10; -.
DR   HGNC; HGNC:2334; CR1.
DR   OpenTargets; ENSG00000203710; -.
DR   eggNOG; ENOG410KDF5; Eukaryota.
DR   eggNOG; ENOG410YE3Q; LUCA.
DR   GeneTree; ENSGT00940000160375; -.
DR   ChiTaRS; CR1; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000203710; Expressed in 135 organ(s), highest expression level in blood.
DR   ExpressionAtlas; E9PQN4; baseline and differential.
DR   CDD; cd00033; CCP; 8.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   Pfam; PF00084; Sushi; 8.
DR   SMART; SM00032; CCP; 9.
DR   SUPFAM; SSF57535; SSF57535; 9.
DR   PROSITE; PS50923; SUSHI; 8.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00302,
KW   ECO:0000256|SAAS:SAAS00887447};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PQN4,
KW   ECO:0000213|PeptideAtlas:E9PQN4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   SIGNAL        1     41       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        42    604       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245440.
FT   DOMAIN       41    101       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      102    163       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      164    234       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      236    293       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      295    355       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      356    418       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      419    489       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      491    551       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DISULFID     43     86       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    266    293       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    297    340       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    326    353       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    493    536       {ECO:0000256|PROSITE-ProRule:PRU00302}.
SQ   SEQUENCE   604 AA;  65983 MW;  A814FF84A0507571 CRC64;
     MGASSPRSPE PVGPPAPGLP FCCGGSLLAV VVLLALPVAW GQCNAPEWLP FARPTNLTDE
     FEFPIGTYLN YECRPGYSGR PFSIICLKNS VWTGAKDRCR RKSCRNPPDP VNGMVHVIKG
     IQFGSQIKYS CTKGYRLIGS SSATCIISGD TVIWDNETPI CDRIPCGLPP TITNGDFIST
     NRENFHYGSV VTYRCNPGSG GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP
     PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP
     PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA PTCEVKSCDD
     FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC VLAGMESLWN SSVPVCEQIF
     CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC DPHPDRGTSF DLIGESTIRC TSDPQGNGVW
     SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL
     VWSSPKDVCK RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGSLSSPR SFSVCQVENP
     NQCI
//