ID   E9PQD6_HUMAN            Unreviewed;       122 AA.
AC   E9PQD6;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 54.
DE   RecName: Full=Serum amyloid A protein {ECO:0000256|RuleBase:RU000539};
GN   Name=SAA1 {ECO:0000313|Ensembl:ENSP00000436866};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436866, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000436866, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000436866}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- FUNCTION: Major acute phase reactant. Apolipoprotein of the HDL
CC       complex. {ECO:0000256|RuleBase:RU000539}.
CC   -!- SIMILARITY: Belongs to the SAA family.
CC       {ECO:0000256|RuleBase:RU000539}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC107948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PQD6; -.
DR   SMR; E9PQD6; -.
DR   jPOST; E9PQD6; -.
DR   PeptideAtlas; E9PQD6; -.
DR   PRIDE; E9PQD6; -.
DR   Ensembl; ENST00000532858; ENSP00000436866; ENSG00000173432.
DR   UCSC; uc057zpv.1; human.
DR   EuPathDB; HostDB:ENSG00000173432.10; -.
DR   HGNC; HGNC:10513; SAA1.
DR   OpenTargets; ENSG00000173432; -.
DR   eggNOG; ENOG410IXU4; Eukaryota.
DR   eggNOG; ENOG410YSBK; LUCA.
DR   GeneTree; ENSGT00390000004737; -.
DR   OMA; FFGHGAE; -.
DR   PhylomeDB; E9PQD6; -.
DR   ChiTaRS; SAA1; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000173432; Expressed in 89 organ(s), highest expression level in liver.
DR   ExpressionAtlas; E9PQD6; baseline and differential.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-UniRule.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-UniRule.
DR   InterPro; IPR000096; Serum_amyloid_A.
DR   Pfam; PF00277; SAA; 1.
DR   PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR   PRINTS; PR00306; SERUMAMYLOID.
DR   SMART; SM00197; SAA; 1.
DR   PROSITE; PS00992; SAA; 1.
PE   1: Evidence at protein level;
KW   Acute phase {ECO:0000256|RuleBase:RU000539};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   HDL {ECO:0000256|RuleBase:RU000539};
KW   Proteomics identification {ECO:0000213|EPD:E9PQD6,
KW   ECO:0000213|MaxQB:E9PQD6, ECO:0000213|PeptideAtlas:E9PQD6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    122       Serum amyloid A protein.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245430.
SQ   SEQUENCE   122 AA;  13546 MW;  8C43BF06AA47B179 CRC64;
     MKLLTGLVFC SLVLGVSSRS FFSFLGEAFD GARDMWRAYS DMREANYIGS DKYFHARGNY
     DAAKRGPGGA WAAEVITDAR ENIQRFFGHG AEDSLADQAA NEWGRSGKDP NHFRPAGLPE
     KY
//