ID   E9PPJ5_HUMAN            Unreviewed;       131 AA.
AC   E9PPJ5;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 48.
DE   SubName: Full=Midkine {ECO:0000313|Ensembl:ENSP00000432649};
DE   Flags: Fragment;
GN   Name=MDK {ECO:0000313|Ensembl:ENSP00000432649};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000432649, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000432649, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000432649}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC116021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PPJ5; -.
DR   EPD; E9PPJ5; -.
DR   jPOST; E9PPJ5; -.
DR   MaxQB; E9PPJ5; -.
DR   PRIDE; E9PPJ5; -.
DR   Ensembl; ENST00000533952; ENSP00000432649; ENSG00000110492.
DR   UCSC; uc058awo.1; human.
DR   EuPathDB; HostDB:ENSG00000110492.15; -.
DR   HGNC; HGNC:6972; MDK.
DR   OpenTargets; ENSG00000110492; -.
DR   eggNOG; ENOG410J0E8; Eukaryota.
DR   eggNOG; ENOG4111ZWP; LUCA.
DR   GeneTree; ENSGT00390000007640; -.
DR   ChiTaRS; MDK; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000110492; Expressed in 91 organ(s), highest expression level in adenohypophysis.
DR   ExpressionAtlas; E9PPJ5; baseline and differential.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   Gene3D; 2.20.60.10; -; 1.
DR   Gene3D; 2.30.90.10; -; 1.
DR   InterPro; IPR000762; Midkine_heparin-bd_GF.
DR   InterPro; IPR020090; PTN/MK_C_dom.
DR   InterPro; IPR038130; PTN/MK_C_dom_sf.
DR   InterPro; IPR020091; PTN/MK_diS_sf.
DR   InterPro; IPR020089; PTN/MK_N_dom.
DR   InterPro; IPR037122; PTN/MK_N_dom_sf.
DR   InterPro; IPR020092; PTN_MK_heparin-bd_GF_CS.
DR   PANTHER; PTHR13850; PTHR13850; 1.
DR   Pfam; PF01091; PTN_MK_C; 1.
DR   Pfam; PF05196; PTN_MK_N; 1.
DR   PRINTS; PR00269; PTNMIDKINE.
DR   ProDom; PD005592; PTN_MK_hepar_bd; 1.
DR   SMART; SM00193; PTN; 1.
DR   SUPFAM; SSF57288; SSF57288; 2.
DR   PROSITE; PS00619; PTN_MK_1; 1.
DR   PROSITE; PS00620; PTN_MK_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PPJ5,
KW   ECO:0000213|PeptideAtlas:E9PPJ5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    131       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242897.
FT   DOMAIN       24     80       PTN_MK_N. {ECO:0000259|Pfam:PF05196}.
FT   DOMAIN       81    131       PTN_MK_C. {ECO:0000259|Pfam:PF01091}.
FT   NON_TER     131    131       {ECO:0000313|Ensembl:ENSP00000432649}.
SQ   SEQUENCE   131 AA;  14374 MW;  7D118E843DBBBDC1 CRC64;
     MQHRGFLLLT LLALLALTSA VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT
     CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI
     RVTKPCTPKT K
//