ID   E9PP23_HUMAN            Unreviewed;       305 AA.
AC   E9PP23;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   SubName: Full=Lysosomal acid phosphatase {ECO:0000313|Ensembl:ENSP00000436487};
DE   Flags: Fragment;
GN   Name=ACP2 {ECO:0000313|Ensembl:ENSP00000436487};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436487, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000436487, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000436487}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC       {ECO:0000256|SAAS:SAAS00793915}.
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DR   EMBL; AC018410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PP23; -.
DR   EPD; E9PP23; -.
DR   jPOST; E9PP23; -.
DR   MaxQB; E9PP23; -.
DR   PeptideAtlas; E9PP23; -.
DR   PRIDE; E9PP23; -.
DR   Ensembl; ENST00000529663; ENSP00000436487; ENSG00000134575.
DR   UCSC; uc058bcc.1; human.
DR   EuPathDB; HostDB:ENSG00000134575.9; -.
DR   HGNC; HGNC:123; ACP2.
DR   OpenTargets; ENSG00000134575; -.
DR   GeneTree; ENSGT00940000158446; -.
DR   ChiTaRS; ACP2; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000134575; Expressed in 218 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; E9PP23; baseline and differential.
DR   CDD; cd07061; HP_HAP_like; 1.
DR   Gene3D; 3.40.50.1240; -; 2.
DR   InterPro; IPR033379; Acid_Pase_AS.
DR   InterPro; IPR000560; His_Pase_clade-2.
DR   InterPro; IPR029033; His_PPase_superfam.
DR   Pfam; PF00328; His_Phos_2; 2.
DR   SUPFAM; SSF53254; SSF53254; 1.
DR   PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
DR   PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E9PP23,
KW   ECO:0000213|MaxQB:E9PP23, ECO:0000213|PeptideAtlas:E9PP23};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31    305       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003244160.
FT   NON_TER     305    305       {ECO:0000313|Ensembl:ENSP00000436487}.
SQ   SEQUENCE   305 AA;  35156 MW;  0866DEA136084A68 CRC64;
     MAGKRSGWSR AALLQLLLGV NLVVMPPTRA RSLRFVTLLY RHGDRSPVKT YPKDPYQEEE
     WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV YVRSTDFDRT LMSAEANLAG
     LFPPNGMQRF NPNISWQPIP VHTVPITEDR QFLDMVANET GLTDLTLETV WNVYDTLFCE
     QTHGLRLPPW ASPQTMQRLS RLKDFSFRFL FGIYQQAEKA RLQGGVLLAQ IRKNLTLMAT
     TSQLPKLLVY SAHDTTLVAL QMALDVYNGE QAPYASCHIF ELYQEDSGNF SVEMYFRNES
     DKAPW
//