ID   E9PNU0_HUMAN            Unreviewed;       252 AA.
AC   E9PNU0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   05-DEC-2018, entry version 51.
DE   SubName: Full=V-type proton ATPase 21 kDa proteolipid subunit {ECO:0000313|Ensembl:ENSP00000432754};
GN   Name=ATP6V0B {ECO:0000313|Ensembl:ENSP00000432754};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000432754, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000432754, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000432754}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the V-ATPase proteolipid subunit family.
CC       {ECO:0000256|RuleBase:RU363060, ECO:0000256|SAAS:SAAS00595979}.
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DR   EMBL; AL357079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PNU0; -.
DR   PRIDE; E9PNU0; -.
DR   Ensembl; ENST00000471859; ENSP00000432754; ENSG00000117410.
DR   UCSC; uc057frg.1; human.
DR   EuPathDB; HostDB:ENSG00000117410.13; -.
DR   HGNC; HGNC:861; ATP6V0B.
DR   OpenTargets; ENSG00000117410; -.
DR   GeneTree; ENSGT00550000075120; -.
DR   OMA; GYVMFGA; -.
DR   ChiTaRS; ATP6V0B; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000117410; Expressed in 224 organ(s), highest expression level in blood.
DR   ExpressionAtlas; E9PNU0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002379; ATPase_proteolipid_c-like_dom.
DR   InterPro; IPR000245; ATPase_proteolipid_csu.
DR   InterPro; IPR035921; F/V-ATP_Csub_sf.
DR   Pfam; PF00137; ATP-synt_C; 2.
DR   PRINTS; PR00122; VACATPASE.
DR   SUPFAM; SSF81333; SSF81333; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ion transport {ECO:0000256|RuleBase:RU363060,
KW   ECO:0000256|SAAS:SAAS00490120};
KW   Membrane {ECO:0000256|RuleBase:RU363060,
KW   ECO:0000256|SAAS:SAAS00490135};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E9PNU0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|RuleBase:RU363060,
KW   ECO:0000256|SAAS:SAAS00490135};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363060,
KW   ECO:0000256|SAAS:SAAS00490135};
KW   Transport {ECO:0000256|RuleBase:RU363060,
KW   ECO:0000256|SAAS:SAAS00490120}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    252       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242888.
FT   TRANSMEM     94    117       Helical. {ECO:0000256|RuleBase:RU363060}.
FT   TRANSMEM    138    162       Helical. {ECO:0000256|RuleBase:RU363060}.
FT   TRANSMEM    182    212       Helical. {ECO:0000256|RuleBase:RU363060}.
FT   TRANSMEM    219    243       Helical. {ECO:0000256|RuleBase:RU363060}.
FT   DOMAIN       99    158       ATP-synt_C. {ECO:0000259|Pfam:PF00137}.
FT   DOMAIN      185    243       ATP-synt_C. {ECO:0000259|Pfam:PF00137}.
SQ   SEQUENCE   252 AA;  26089 MW;  03F681EE652C47D5 CRC64;
     MTGLALLYSG VFVAFWACAL AVGEAGSWRA GAASRPSWPG RNSAGKWPAG NTGPPRALHP
     RLWGLAPARA SDSDKGDPDF QLLEEGFLTE TSPFMWSNLG IGLAISLSVV GAAWGIYITG
     SSIIGGGVKA PRIKTKNLVS IIFCEAVAIY GIIMAIVISN MAEPFSATDP KAIGHRNYHA
     GYSMFGAGLT VGLSNLFCGV CVGIVGSGAA LADAQNPSLF VKILIVEIFG SAIGLFGVIV
     AILQTSRVKM GD
//