ID   E9PNJ5_HUMAN            Unreviewed;       133 AA.
AC   E9PNJ5;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   05-DEC-2018, entry version 52.
DE   SubName: Full=Low-density lipoprotein receptor-related protein 4 {ECO:0000313|Ensembl:ENSP00000434763};
DE   Flags: Fragment;
GN   Name=LRP4 {ECO:0000313|Ensembl:ENSP00000434763};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434763, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000434763, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000434763}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC021573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PNJ5; -.
DR   PeptideAtlas; E9PNJ5; -.
DR   PRIDE; E9PNJ5; -.
DR   Ensembl; ENST00000534404; ENSP00000434763; ENSG00000134569.
DR   UCSC; uc058azd.1; human.
DR   EuPathDB; HostDB:ENSG00000134569.9; -.
DR   HGNC; HGNC:6696; LRP4.
DR   OpenTargets; ENSG00000134569; -.
DR   eggNOG; KOG1215; Eukaryota.
DR   eggNOG; ENOG410XPR2; LUCA.
DR   GeneTree; ENSGT00940000158287; -.
DR   ChiTaRS; LRP4; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000134569; Expressed in 186 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; E9PNJ5; baseline and differential.
DR   GO; GO:0048513; P:animal organ development; IEA:InterPro.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:InterPro.
DR   GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IEA:InterPro.
DR   CDD; cd00112; LDLa; 3.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR030799; LRP4.
DR   PANTHER; PTHR44017:SF4; PTHR44017:SF4; 1.
DR   Pfam; PF00057; Ldl_recept_a; 3.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00192; LDLa; 3.
DR   SUPFAM; SSF57424; SSF57424; 3.
DR   PROSITE; PS01209; LDLRA_1; 2.
DR   PROSITE; PS50068; LDLRA_2; 3.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124,
KW   ECO:0000256|SAAS:SAAS00895822};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E9PNJ5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    133       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242919.
FT   DISULFID     22     34       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID     29     47       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID     41     56       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID     61     73       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID     68     86       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID     99    111       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    106    124       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    118    133       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   NON_TER     133    133       {ECO:0000313|Ensembl:ENSP00000434763}.
SQ   SEQUENCE   133 AA;  15097 MW;  AEAA3B7CFCE45FE2 CRC64;
     MRRQWGALLL GALLCAHVLP TCSPLDFHCD NGKCIRRSWV CDGDNDCEDD SDEQDCPPRE
     CEEDEFPCQN GYCIRSLWHC DGDNDCGDNS DEQCDMRKCS DKEFRCSDGS CIAEHWYCDG
     DTDCKDGSDE ENC
//