ID   E9PN58_HUMAN            Unreviewed;       353 AA.
AC   E9PN58;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=NAD-dependent protein deacetylase sirtuin-3, mitochondrial {ECO:0000313|Ensembl:ENSP00000432937};
GN   Name=SIRT3 {ECO:0000313|Ensembl:ENSP00000432937};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000432937, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000432937, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000432937}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [4] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AC136475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PN58; -.
DR   jPOST; E9PN58; -.
DR   MaxQB; E9PN58; -.
DR   PeptideAtlas; E9PN58; -.
DR   PRIDE; E9PN58; -.
DR   Ensembl; ENST00000524564; ENSP00000432937; ENSG00000142082.
DR   UCSC; uc010qvm.3; human.
DR   EuPathDB; HostDB:ENSG00000142082.14; -.
DR   HGNC; HGNC:14931; SIRT3.
DR   OpenTargets; ENSG00000142082; -.
DR   GeneTree; ENSGT00940000159464; -.
DR   ChiTaRS; SIRT3; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000142082; Expressed in 214 organ(s), highest expression level in anterior cingulate cortex.
DR   ExpressionAtlas; E9PN58; baseline and differential.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   Gene3D; 3.30.1600.10; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR003000; Sirtuin.
DR   InterPro; IPR026591; Sirtuin_cat_small_dom_sf.
DR   InterPro; IPR026590; Ssirtuin_cat_dom.
DR   Pfam; PF02146; SIR2; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   PROSITE; PS50305; SIRTUIN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E9PN58,
KW   ECO:0000213|MaxQB:E9PN58, ECO:0000213|PeptideAtlas:E9PN58};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    353       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242882.
FT   DOMAIN       61    318       Deacetylase sirtuin-type.
FT                                {ECO:0000259|PROSITE:PS50305}.
SQ   SEQUENCE   353 AA;  39175 MW;  FA4DD75397FE208E CRC64;
     MAFWGWRAAA ALRLWGRVVE RVEAGGGVGP FQACGCRLVL GGRDDVSAGL RGSHGARGEP
     LDPARPLQRP PRPEVPRAFR RQPRAAAPSF FFSRSPGSGL YSNLQQYDLP YPEAIFELPF
     FFHNPKPFFT LAKELYPGNY KPNVTHYFLR LLHDKGLLLR LYTQNIDGLE RVSGIPASKL
     VEAHGTFASA TCTVCQRPFP GEDIRADVMA DRVPRCPVCT GVVKPDIVFF GEPLPQRFLL
     HVVDFPMADL LLILGTSLEV EPFASLTEAV RSSVPRLLIN RDLVGPLAWH PRSRDVAQLG
     DVVHGVESLV ELLGWTEEMR DLVQRETGKV QTAEEDHPRG CPSHCSRLDG PDK
//