ID   E9PMT5_HUMAN            Unreviewed;        98 AA.
AC   E9PMT5;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 73.
DE   SubName: Full=T-cell surface glycoprotein CD3 delta chain {ECO:0000313|Ensembl:ENSP00000437335};
GN   Name=CD3D {ECO:0000313|EMBL:AEQ93556.1,
GN   ECO:0000313|Ensembl:ENSP00000437335};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000437335, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000213|PubMed:12522270}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=12522270; DOI=10.1073/pnas.2436191100;
RA   Salomon A.R., Ficarro S.B., Brill L.M., Brinker A., Phung Q.T.,
RA   Ericson C., Sauer K., Brock A., Horn D.M., Schultz P.G., Peters E.C.;
RT   "Profiling of tyrosine phosphorylation pathways in human cells using
RT   mass spectrometry.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003).
RN   [2] {ECO:0000213|PubMed:15144186}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=15144186; DOI=10.1021/ac035352d;
RA   Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,
RA   Peters E.C.;
RT   "Robust phosphoproteomic profiling of tyrosine phosphorylation sites
RT   from human T cells using immobilized metal affinity chromatography and
RT   tandem mass spectrometry.";
RL   Anal. Chem. 76:2763-2772(2004).
RN   [3] {ECO:0000313|Ensembl:ENSP00000437335, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [4] {ECO:0000213|PubMed:19690332}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:ra46-RA46(2009).
RN   [5] {ECO:0000313|EMBL:AEQ93556.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Recio M.J., Regueiro J.R.;
RT   "A leaky mutation in CD3D leads to a Tab-Tgd+B+NK+ human SCID.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|Ensembl:ENSP00000437335}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP001582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JN392069; AEQ93556.1; -; mRNA.
DR   UniGene; Hs.504048; -.
DR   jPOST; E9PMT5; -.
DR   PeptideAtlas; E9PMT5; -.
DR   PRIDE; E9PMT5; -.
DR   Ensembl; ENST00000529594; ENSP00000437335; ENSG00000167286.
DR   UCSC; uc021qrf.2; human.
DR   EuPathDB; HostDB:ENSG00000167286.9; -.
DR   HGNC; HGNC:1673; CD3D.
DR   OpenTargets; ENSG00000167286; -.
DR   eggNOG; ENOG410IWAX; Eukaryota.
DR   eggNOG; ENOG410Y2TD; LUCA.
DR   GeneTree; ENSGT00940000153312; -.
DR   ChiTaRS; CD3D; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000167286; Expressed in 166 organ(s), highest expression level in thymus.
DR   ExpressionAtlas; E9PMT5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042101; C:T cell receptor complex; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR015484; CD3_esu/gsu/dsu.
DR   InterPro; IPR015485; CD3D.
DR   InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
DR   PANTHER; PTHR10570; PTHR10570; 1.
DR   PANTHER; PTHR10570:SF5; PTHR10570:SF5; 1.
DR   Pfam; PF02189; ITAM; 1.
DR   SMART; SM00077; ITAM; 1.
DR   PROSITE; PS51055; ITAM_1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PMT5,
KW   ECO:0000213|PeptideAtlas:E9PMT5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23     98       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014089027.
FT   TRANSMEM     31     53       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   98 AA;  10530 MW;  A61BD831A93F20D1 CRC64;
     MEHSTFLSGL VLATLLSQVC QSCVELDPAT VAGIIVTDVI ATLLLALGVF CFAGHETGRL
     SGAADTQALL RNDQVYQPLR DRDDAQYSHL GGNWARNK
//