ID   E9PLZ7_HUMAN            Unreviewed;       150 AA.
AC   E9PLZ7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   05-DEC-2018, entry version 48.
DE   SubName: Full=Sodium-coupled monocarboxylate transporter 2 {ECO:0000313|Ensembl:ENSP00000435053};
DE   Flags: Fragment;
GN   Name=SLC5A12 {ECO:0000313|Ensembl:ENSP00000435053};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000435053, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000435053, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000435053}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC
CC       2.A.21) family. {ECO:0000256|RuleBase:RU362091}.
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DR   EMBL; AC083755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PLZ7; -.
DR   PeptideAtlas; E9PLZ7; -.
DR   Ensembl; ENST00000533617; ENSP00000435053; ENSG00000148942.
DR   UCSC; uc057zxo.1; human.
DR   EuPathDB; HostDB:ENSG00000148942.14; -.
DR   HGNC; HGNC:28750; SLC5A12.
DR   OpenTargets; ENSG00000148942; -.
DR   eggNOG; KOG2349; Eukaryota.
DR   eggNOG; COG0591; LUCA.
DR   GeneTree; ENSGT00940000159545; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000148942; Expressed in 87 organ(s), highest expression level in intestine.
DR   ExpressionAtlas; E9PLZ7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1730.10; -; 1.
DR   InterPro; IPR038377; Na/Glc_symporter_sf.
DR   InterPro; IPR001734; Na/solute_symporter.
DR   Pfam; PF00474; SSF; 1.
DR   PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PLZ7,
KW   ECO:0000213|PeptideAtlas:E9PLZ7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    150       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008413951.
FT   TRANSMEM     48     67       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     88    110       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    130    149       Helical. {ECO:0000256|SAM:Phobius}.
FT   NON_TER     150    150       {ECO:0000313|Ensembl:ENSP00000435053}.
SQ   SEQUENCE   150 AA;  16793 MW;  F6DA5AA8DFADAD74 CRC64;
     MVVMIVGFLT VLIQGSTHAG GFHNVLEQST NGSRLHIFDF DVDPLRRHTF WTITVGGTFT
     WLGIYGVNQS TIQRCISCKT EKHAKLALYF NLLGLWIILV CAVFSGLIMY SHFKDCDPWT
     SGIISAPDQL MPYFVMEIFA TMPGLPGLFV
//