ID   E9PLR0_HUMAN            Unreviewed;       195 AA.
AC   E9PLR0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 49.
DE   SubName: Full=Nucleobindin-2 {ECO:0000313|Ensembl:ENSP00000431334};
DE   Flags: Fragment;
GN   Name=NUCB2 {ECO:0000313|Ensembl:ENSP00000431334};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000431334, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000431334, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000431334}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AC107956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PLR0; -.
DR   jPOST; E9PLR0; -.
DR   MaxQB; E9PLR0; -.
DR   PeptideAtlas; E9PLR0; -.
DR   PRIDE; E9PLR0; -.
DR   Ensembl; ENST00000529313; ENSP00000431334; ENSG00000070081.
DR   UCSC; uc057zmg.1; human.
DR   EuPathDB; HostDB:ENSG00000070081.15; -.
DR   HGNC; HGNC:8044; NUCB2.
DR   OpenTargets; ENSG00000070081; -.
DR   eggNOG; KOG3866; Eukaryota.
DR   eggNOG; ENOG410XW7D; LUCA.
DR   GeneTree; ENSGT00390000001927; -.
DR   ChiTaRS; NUCB2; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000070081; Expressed in 231 organ(s), highest expression level in saliva-secreting gland.
DR   ExpressionAtlas; E9PLR0; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0032099; P:negative regulation of appetite; IEA:InterPro.
DR   InterPro; IPR028813; NUCB2.
DR   InterPro; IPR040250; Nucleobindin.
DR   PANTHER; PTHR19237; PTHR19237; 1.
DR   PANTHER; PTHR19237:SF22; PTHR19237:SF22; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E9PLR0,
KW   ECO:0000213|MaxQB:E9PLR0, ECO:0000213|PeptideAtlas:E9PLR0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    195       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245138.
FT   NON_TER     195    195       {ECO:0000313|Ensembl:ENSP00000431334}.
SQ   SEQUENCE   195 AA;  23186 MW;  4B85954480656777 CRC64;
     MRWRTILLQY CFLLITCLLT ALEAVPIDID KTKVQNIHPV ESAKIEPPDT GLYYDEYLKQ
     VIDVLETDKH FREKLQKADI EEIKSGRLSK ELDLVSHHVR TKLDELKRQE VGRLRMLIKA
     KLDSLQDIGM DHQALLKQFD HLNHLNPDKF ESTDLDMLIK AATSDLEHYD KTRHEEFKKY
     EMMKEHERRE YLKTL
//