ID   E9PLM6_HUMAN            Unreviewed;       156 AA.
AC   E9PLM6;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 54.
DE   SubName: Full=Midkine {ECO:0000313|Ensembl:ENSP00000433240};
GN   Name=MDK {ECO:0000313|Ensembl:ENSP00000433240};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000433240, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000433240, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000433240}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC116021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PLM6; -.
DR   jPOST; E9PLM6; -.
DR   MaxQB; E9PLM6; -.
DR   PRIDE; E9PLM6; -.
DR   Ensembl; ENST00000489525; ENSP00000433240; ENSG00000110492.
DR   UCSC; uc058awr.1; human.
DR   EuPathDB; HostDB:ENSG00000110492.15; -.
DR   HGNC; HGNC:6972; MDK.
DR   OpenTargets; ENSG00000110492; -.
DR   eggNOG; ENOG410J0E8; Eukaryota.
DR   eggNOG; ENOG4111ZWP; LUCA.
DR   GeneTree; ENSGT00390000007640; -.
DR   OMA; EWTWGPC; -.
DR   PhylomeDB; E9PLM6; -.
DR   ChiTaRS; MDK; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000110492; Expressed in 91 organ(s), highest expression level in adenohypophysis.
DR   ExpressionAtlas; E9PLM6; baseline and differential.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   Gene3D; 2.20.60.10; -; 1.
DR   Gene3D; 2.30.90.10; -; 1.
DR   InterPro; IPR000762; Midkine_heparin-bd_GF.
DR   InterPro; IPR020090; PTN/MK_C_dom.
DR   InterPro; IPR038130; PTN/MK_C_dom_sf.
DR   InterPro; IPR020091; PTN/MK_diS_sf.
DR   InterPro; IPR020089; PTN/MK_N_dom.
DR   InterPro; IPR037122; PTN/MK_N_dom_sf.
DR   InterPro; IPR020092; PTN_MK_heparin-bd_GF_CS.
DR   PANTHER; PTHR13850; PTHR13850; 1.
DR   Pfam; PF01091; PTN_MK_C; 1.
DR   Pfam; PF05196; PTN_MK_N; 1.
DR   PRINTS; PR00269; PTNMIDKINE.
DR   ProDom; PD005592; PTN_MK_hepar_bd; 1.
DR   SMART; SM00193; PTN; 1.
DR   SUPFAM; SSF57288; SSF57288; 2.
DR   PROSITE; PS00619; PTN_MK_1; 1.
DR   PROSITE; PS00620; PTN_MK_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PLM6,
KW   ECO:0000213|PeptideAtlas:E9PLM6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    156       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242856.
FT   DOMAIN       24     80       PTN_MK_N. {ECO:0000259|Pfam:PF05196}.
FT   DOMAIN       81    142       PTN_MK_C. {ECO:0000259|Pfam:PF01091}.
SQ   SEQUENCE   156 AA;  16926 MW;  D22E8DEA5D234A57 CRC64;
     MQHRGFLLLT LLALLALTSA VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT
     CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI
     RVTKPCTPKT KAKAKGQRKE KGVGLSRGAA PPPPRL
//