ID   E9PL79_HUMAN            Unreviewed;       512 AA.
AC   E9PL79;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 57.
DE   SubName: Full=Sialic acid-binding Ig-like lectin 10 {ECO:0000313|Ensembl:ENSP00000431444};
GN   Name=SIGLEC10 {ECO:0000313|Ensembl:ENSP00000431444};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000431444, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000431444, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000431444}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC008750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001309034.1; NM_001322105.1.
DR   UniGene; Hs.284813; -.
DR   ProteinModelPortal; E9PL79; -.
DR   jPOST; E9PL79; -.
DR   MaxQB; E9PL79; -.
DR   PeptideAtlas; E9PL79; -.
DR   PRIDE; E9PL79; -.
DR   Ensembl; ENST00000525998; ENSP00000431444; ENSG00000142512.
DR   GeneID; 89790; -.
DR   UCSC; uc010ycy.3; human.
DR   CTD; 89790; -.
DR   EuPathDB; HostDB:ENSG00000142512.14; -.
DR   HGNC; HGNC:15620; SIGLEC10.
DR   OpenTargets; ENSG00000142512; -.
DR   GeneTree; ENSGT00940000153211; -.
DR   OrthoDB; 1124645at2759; -.
DR   ChiTaRS; SIGLEC10; human.
DR   GenomeRNAi; 89790; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000142512; Expressed in 145 organ(s), highest expression level in blood.
DR   ExpressionAtlas; E9PL79; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 1.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   PROSITE; PS50835; IG_LIKE; 2.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00653601};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PL79,
KW   ECO:0000213|PeptideAtlas:E9PL79};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    512       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245315.
FT   TRANSMEM    366    386       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      146    231       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      254    351       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   512 AA;  56796 MW;  F9D4F00EA24C793C CRC64;
     MLLPLLLSSL LGGSQAMDGR FWIRVQESVM VPEGLCISVP CSFSYPRQDW TGSTPAYGYW
     FKAVTETTKG APVATNHQSR EVEMSTRGRF QLTGDPAKGN CSLVIRDAQM QDESQYFFRV
     ERGSYVRYNF MNDGFFLKVT ALTQKPDVYI PETLEPGQPV TVICVFNWAF EECPPPSFSW
     TGAALSSQGT KPTTSHFSVL SFTPRPQDHN TDLTCHVDFS RKGVSAQRTV RLRVAYAPRD
     LVISISRDNT PDPPENLRVM VSQANRTVLE NLGNGTSLPV LEGQSLCLVC VTHSSPPARL
     SWTQRGQVLS PSQPSDPGVL ELPRVQVEHE GEFTCHARHP LGSQHVSLSL SVHYKKGLIS
     TAFSNGAFLG IGITALLFLC LALIIMKILP KRRTQTETPR PRFSRHSTIL DYINVVPTAG
     PLAQKRNQKA TPNSPRTPLP PGAPSPESKK NQKKQYQLPS FPEPKSSTQA PESQESQEEL
     HYATLNFPGV RPRPEARMPK GTQADYAEVK FQ
//