ID   E9PL32_HUMAN            Unreviewed;        68 AA.
AC   E9PL32;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   16-JAN-2019, entry version 56.
DE   SubName: Full=Cathepsin B {ECO:0000313|Ensembl:ENSP00000433379};
DE   Flags: Fragment;
GN   Name=CTSB {ECO:0000313|Ensembl:ENSP00000433379};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000433379, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000433379, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000433379}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC025857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC069185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; E9PL32; -.
DR   PeptideAtlas; E9PL32; -.
DR   PRIDE; E9PL32; -.
DR   Ensembl; ENST00000527215; ENSP00000433379; ENSG00000164733.
DR   UCSC; uc064kik.1; human.
DR   EuPathDB; HostDB:ENSG00000164733.20; -.
DR   HGNC; HGNC:2527; CTSB.
DR   OpenTargets; ENSG00000164733; -.
DR   eggNOG; KOG1543; Eukaryota.
DR   eggNOG; COG4870; LUCA.
DR   GeneTree; ENSGT00940000158680; -.
DR   ChiTaRS; CTSB; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000164733; Expressed in 232 organ(s), highest expression level in thyroid gland.
DR   ExpressionAtlas; E9PL32; baseline and differential.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:InterPro.
DR   InterPro; IPR012599; Propeptide_C1A.
DR   Pfam; PF08127; Propeptide_C1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PL32,
KW   ECO:0000213|PeptideAtlas:E9PL32};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18     68       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245125.
FT   DOMAIN       26     63       Propeptide_C1.
FT                                {ECO:0000259|Pfam:PF08127}.
FT   NON_TER      68     68       {ECO:0000313|Ensembl:ENSP00000433379}.
SQ   SEQUENCE   68 AA;  7831 MW;  8E3105E003BD1C21 CRC64;
     MWQLWASLCC LLVLANARSR PSFHPLSDEL VNYVNKRNTT WQAGHNFYNV DMSYLKRLCG
     TFLGGPKP
//