ID   E9PKW6_HUMAN            Unreviewed;       234 AA.
AC   E9PKW6;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 48.
DE   SubName: Full=Dickkopf-related protein 3 {ECO:0000313|Ensembl:ENSP00000435269};
DE   Flags: Fragment;
GN   Name=DKK3 {ECO:0000313|Ensembl:ENSP00000435269};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000435269, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000435269, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000435269}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC124276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PKW6; -.
DR   SMR; E9PKW6; -.
DR   jPOST; E9PKW6; -.
DR   PeptideAtlas; E9PKW6; -.
DR   PRIDE; E9PKW6; -.
DR   Ensembl; ENST00000533813; ENSP00000435269; ENSG00000050165.
DR   UCSC; uc057zdo.1; human.
DR   EuPathDB; HostDB:ENSG00000050165.17; -.
DR   HGNC; HGNC:2893; DKK3.
DR   OpenTargets; ENSG00000050165; -.
DR   eggNOG; ENOG410IRWK; Eukaryota.
DR   eggNOG; ENOG4111WWP; LUCA.
DR   GeneTree; ENSGT00390000000221; -.
DR   ChiTaRS; DKK3; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000050165; Expressed in 230 organ(s), highest expression level in primary visual cortex.
DR   ExpressionAtlas; E9PKW6; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0007275; P:multicellular organism development; IEA:InterPro.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR   InterPro; IPR006796; Dickkopf_N.
DR   InterPro; IPR039863; DKK-like.
DR   PANTHER; PTHR12113; PTHR12113; 1.
DR   Pfam; PF04706; Dickkopf_N; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PKW6,
KW   ECO:0000213|PeptideAtlas:E9PKW6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    234       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008413947.
FT   DOMAIN      146    196       Dickkopf_N. {ECO:0000259|Pfam:PF04706}.
FT   COILED       40     78       {ECO:0000256|SAM:Coils}.
FT   NON_TER     234    234       {ECO:0000313|Ensembl:ENSP00000435269}.
SQ   SEQUENCE   234 AA;  25632 MW;  77EE7362B095D7BE CRC64;
     MQRLGATLLC LLLAAAVPTA PAPAPTATSA PVKPGPALSY PQEEATLNEM FREVEELMED
     TQHKLRSAVE EMEAEEAAAK ASSEVNLANL PPSYHNETNT DTKVGNNTIH VHREIHKITN
     NQTGQMVFSE TVITSVGDEE GRRSHECIID EDCGPSMYCQ FASFQYTCQP CRGQRMLCTR
     DSECCGDQLC VWGHCTKMAT RGSNGTICDN QRDCQPGLCC AFQRGLLFPV CTPL
//