ID   E9PKP3_HUMAN            Unreviewed;       381 AA.
AC   E9PKP3;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 64.
DE   SubName: Full=Transmembrane protein 25 {ECO:0000313|Ensembl:ENSP00000431548};
GN   Name=TMEM25 {ECO:0000313|Ensembl:ENSP00000431548};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000431548, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000431548, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000431548}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP000941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001305684.1; NM_001318755.1.
DR   UniGene; Hs.564188; -.
DR   ProteinModelPortal; E9PKP3; -.
DR   jPOST; E9PKP3; -.
DR   PeptideAtlas; E9PKP3; -.
DR   PRIDE; E9PKP3; -.
DR   Ensembl; ENST00000533102; ENSP00000431548; ENSG00000149582.
DR   GeneID; 84866; -.
DR   UCSC; uc001ptk.5; human.
DR   CTD; 84866; -.
DR   EuPathDB; HostDB:ENSG00000149582.15; -.
DR   HGNC; HGNC:25890; TMEM25.
DR   OpenTargets; ENSG00000149582; -.
DR   eggNOG; ENOG410IF2Y; Eukaryota.
DR   eggNOG; ENOG410ZNWF; LUCA.
DR   GeneTree; ENSGT00940000154178; -.
DR   OMA; PQLAWYL; -.
DR   OrthoDB; 914115at2759; -.
DR   PhylomeDB; E9PKP3; -.
DR   ChiTaRS; TMEM25; human.
DR   GenomeRNAi; 84866; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149582; Expressed in 150 organ(s), highest expression level in cerebellum.
DR   ExpressionAtlas; E9PKP3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF08205; C2-set_2; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00504776};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS01086444};
KW   Membrane {ECO:0000256|SAAS:SAAS00555568, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E9PKP3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00555568,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00555568,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    381       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242838.
FT   TRANSMEM    235    261       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       30    123       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   381 AA;  40795 MW;  8C85ACB3595E7F9C CRC64;
     MALPPGPAAL RHTLLLLPAL LSSGWGELEP QIDGQTWAER ALRENERHAF TCRVAGGPGT
     PRLAWYLDGQ LQEASTSRLL SVGGEAFSGG TSTFTVTAHR AQHELNCSLQ DPRSGRSANA
     SVILNVQFKP EIAQVGAKYQ EAQGPGLLVV LFALVRANPP ANVTWIDQDG PVTVNTSDFL
     VLDAQNYPWL TNHTVQLQLR SLAHNLSVVA TNDVGVTSAS LPAPGLLATR VEVPLLGIVV
     AAGLALGTLV GFSTLVACLV CRKEKKTKGP SRHPSLISSD SNNLKLNNVR LPRENMSLPS
     NLQLNDLTPD SRVKPADRQM AQNNSRPELL DPEPGGLLTS QACLLHHGTP ALTNPWLPHQ
     QEGALPGGWS PQAHNSTVWK L
//