ID   E9PKH0_HUMAN            Unreviewed;       600 AA.
AC   E9PKH0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 2.
DT   16-JAN-2019, entry version 61.
DE   SubName: Full=Receptor-type tyrosine-protein phosphatase C {ECO:0000313|Ensembl:ENSP00000433536};
DE   Flags: Fragment;
GN   Name=PTPRC {ECO:0000313|Ensembl:ENSP00000433536};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000433536, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000433536, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000433536}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00160}.
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DR   EMBL; AL157402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL355988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PKH0; -.
DR   jPOST; E9PKH0; -.
DR   PeptideAtlas; E9PKH0; -.
DR   PRIDE; E9PKH0; -.
DR   Ensembl; ENST00000530727; ENSP00000433536; ENSG00000081237.
DR   UCSC; uc009wzf.3; human.
DR   EuPathDB; HostDB:ENSG00000081237.18; -.
DR   HGNC; HGNC:9666; PTPRC.
DR   OpenTargets; ENSG00000081237; -.
DR   GeneTree; ENSGT00940000159457; -.
DR   ChiTaRS; PTPRC; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000081237; Expressed in 219 organ(s), highest expression level in blood.
DR   ExpressionAtlas; E9PKH0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IEA:InterPro.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 2.60.40.10; -; 2.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR024739; PTP_recept_N.
DR   InterPro; IPR000242; PTPase_domain.
DR   InterPro; IPR016335; Ptprc.
DR   Pfam; PF12567; CD45; 1.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF12453; PTP_N; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   SMART; SM00060; FN3; 2.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS50853; FN3; 2.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00897767, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:E9PKH0,
KW   ECO:0000213|MaxQB:E9PKH0, ECO:0000213|PeptideAtlas:E9PKH0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    600       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242836.
FT   TRANSMEM    464    485       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      277    369       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      370    462       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      539    600       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   NON_TER     600    600       {ECO:0000313|Ensembl:ENSP00000433536}.
SQ   SEQUENCE   600 AA;  67888 MW;  A0D6E743E843EFF1 CRC64;
     MTMYLWLKLL AFGFAFLDTE VFVTGQSPTP SPTGVSSVQT PHLPTHADSQ TPSAGTDTQT
     FSGSAANAKL NPTPGSNAIS DAYLNASETT TLSPSGSAVI STTTIATTPS KPTCDEKYAN
     ITVDYLYNKE TKLFTAKLNV NENVECGNNT CTNNEVHNLT ECKNASVSIS HNSCTAPDKT
     LILDVPPGVE KFQLHDCTQV EKADTTICLK WKNIETFTCD TQNITYRFQC GNMIFDNKEI
     KLENLEPEHE YKCDSEILYN NHKFTNASKI IKTDFGSPGE PQIIFCRSEA AHQGVITWNP
     PQRSFHNFTL CYIKETEKDC LNLDKNLIKY DLQNLKPYTK YVLSLHAYII AKVQRNGSAA
     MCHFTTKSAP PSQVWNMTVS MTSDNSMHVK CRPPRDRNGP HERYHLEVEA GNTLVRNESH
     KNCDFRVKDL QYSTDYTFKA YFHNGDYPGE PFILHHSTSY NSKALIAFLA FLIIVTSIAL
     LVVLYKIYDL HKKRSCNLDE QQELVERDDE KQLMNVEPIH ADILLETYKR KIADEGRLFL
     AEFQSIPRVF SKFPIKEARK PFNQNKNRYV DILPYDYNRV ELSEINGDAG SNYINASYID
//