ID E9PKG2_HUMAN Unreviewed; 392 AA. AC E9PKG2; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 05-DEC-2018, entry version 55. DE SubName: Full=Low-density lipoprotein receptor-related protein 8 {ECO:0000313|Ensembl:ENSP00000433554}; GN Name=LRP8 {ECO:0000313|Ensembl:ENSP00000433554}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000433554, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000433554, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., RA Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., RA James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., RA Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., RA Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., RA Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., RA Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., RA Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., RA Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., RA Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., RA Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., RA Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., RA Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., RA Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., RA Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., RA Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., RA Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., RA Porter K.M., Prigmore E.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000433554} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL355483; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL606760; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9PKG2; -. DR MaxQB; E9PKG2; -. DR PeptideAtlas; E9PKG2; -. DR PRIDE; E9PKG2; -. DR Ensembl; ENST00000480045; ENSP00000433554; ENSG00000157193. DR UCSC; uc057grk.1; human. DR EuPathDB; HostDB:ENSG00000157193.14; -. DR HGNC; HGNC:6700; LRP8. DR OpenTargets; ENSG00000157193; -. DR eggNOG; ENOG410IPT5; Eukaryota. DR eggNOG; ENOG410YQ6J; LUCA. DR GeneTree; ENSGT00940000154819; -. DR ChiTaRS; LRP8; human. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000157193; Expressed in 200 organ(s), highest expression level in pigmented layer of retina. DR ExpressionAtlas; E9PKG2; baseline and differential. DR CDD; cd00112; LDLa; 6. DR InterPro; IPR036055; LDL_receptor-like_sf. DR InterPro; IPR023415; LDLR_class-A_CS. DR InterPro; IPR002172; LDrepeatLR_classA_rpt. DR Pfam; PF00057; Ldl_recept_a; 8. DR PRINTS; PR00261; LDLRECEPTOR. DR SMART; SM00192; LDLa; 8. DR SUPFAM; SSF57424; SSF57424; 8. DR PROSITE; PS01209; LDLRA_1; 3. DR PROSITE; PS50068; LDLRA_2; 8. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124, KW ECO:0000256|SAAS:SAAS01050632}; KW Proteomics identification {ECO:0000213|PeptideAtlas:E9PKG2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 32 {ECO:0000256|SAM:SignalP}. FT CHAIN 33 392 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003245109. FT DISULFID 47 59 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 54 72 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 66 81 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 86 98 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 93 111 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 148 163 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 167 179 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 174 192 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 186 201 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 267 285 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 279 294 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 299 311 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 306 324 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 318 333 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 347 365 {ECO:0000256|PROSITE-ProRule:PRU00124}. SQ SEQUENCE 392 AA; 42361 MW; 525AC59EC1D1FC85 CRC64; MGLPEPGPLR LLALLLLLLL LLLLQLQHLA AAAADPLLGG QGPAKDCEKD QFQCRNERCI PSVWRCDEDD DCLDHSDEDD CPKKTCADSD FTCDNGHCIH ERWKCDGEEE CPDGSDESEA TCTKQVCPAE KLSCGPTSHK CVPASWRCDG EKDCEGGADE AGCATLCAPH EFQCGNRSCL AAVFVCDGDD DCGDGSDERG CADPACGPRE FRCGGDGGGA CIPERWVCDR QFDCEDRSDE AAELCGRPGP GATSAPAACA TASQFACRSG ECVHLGWRCD GDRDCKDKSD EADCPLGTCR GDEFQCGDGT CVLAIKHCNQ EQDCPDGSDE AGCLQESPCE GPRRFQCKSG KRVDGGKVCD VQRDCRDWSD ELLKVWAERV SAQQWRLLTH LH //