ID   E9PKC6_HUMAN            Unreviewed;        78 AA.
AC   E9PKC6;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   13-FEB-2019, entry version 58.
DE   SubName: Full=CD44 antigen {ECO:0000313|Ensembl:ENSP00000435377};
GN   Name=CD44 {ECO:0000313|Ensembl:ENSP00000435377};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000435377, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000435377, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000213|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [3] {ECO:0000213|PubMed:19690332}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:ra46-RA46(2009).
RN   [4] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [5] {ECO:0000313|Ensembl:ENSP00000435377}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [6] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00323}.
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DR   EMBL; AL133330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL136989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL356215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PKC6; -.
DR   SwissPalm; E9PKC6; -.
DR   jPOST; E9PKC6; -.
DR   MaxQB; E9PKC6; -.
DR   PeptideAtlas; E9PKC6; -.
DR   PRIDE; E9PKC6; -.
DR   Ensembl; ENST00000526025; ENSP00000435377; ENSG00000026508.
DR   UCSC; uc058aik.1; human.
DR   EuPathDB; HostDB:ENSG00000026508.16; -.
DR   HGNC; HGNC:1681; CD44.
DR   OpenTargets; ENSG00000026508; -.
DR   eggNOG; ENOG410IZCP; Eukaryota.
DR   eggNOG; ENOG4111S6T; LUCA.
DR   GeneTree; ENSGT00530000063822; -.
DR   ChiTaRS; CD44; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000026508; Expressed in 228 organ(s), highest expression level in parotid gland.
DR   ExpressionAtlas; E9PKC6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR001231; CD44_antigen.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR000538; Link_dom.
DR   PANTHER; PTHR10225:SF6; PTHR10225:SF6; 1.
DR   Pfam; PF00193; Xlink; 1.
DR   PRINTS; PR00658; CD44.
DR   SMART; SM00445; LINK; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS50963; LINK_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E9PKC6,
KW   ECO:0000213|MaxQB:E9PKC6, ECO:0000213|PeptideAtlas:E9PKC6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21     78       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245107.
FT   DOMAIN       32     78       Link. {ECO:0000259|PROSITE:PS50963}.
SQ   SEQUENCE   78 AA;  8812 MW;  47F418A5EB56939D CRC64;
     MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA DLCKAFNSTL
     PTMAQMEKAL SIGFETCR
//