ID E9PK80_HUMAN Unreviewed; 318 AA. AC E9PK80; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 13-FEB-2019, entry version 57. DE RecName: Full=NAD-dependent protein deacetylase {ECO:0000256|PIRNR:PIRNR037938}; DE EC=3.5.1.- {ECO:0000256|PIRNR:PIRNR037938}; GN Name=SIRT3 {ECO:0000313|Ensembl:ENSP00000435464}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000435464, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000435464, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000435464} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- FUNCTION: NAD-dependent protein deacetylase. CC {ECO:0000256|PIRNR:PIRNR037938}. CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O- CC acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; CC Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; CC Evidence={ECO:0000256|PIRNR:PIRNR037938}; CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|PIRNR:PIRNR037938}; CC -!- SIMILARITY: Belongs to the sirtuin family. Class I subfamily. CC {ECO:0000256|PIRNR:PIRNR037938}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC136475; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9PK80; -. DR jPOST; E9PK80; -. DR MaxQB; E9PK80; -. DR PeptideAtlas; E9PK80; -. DR PRIDE; E9PK80; -. DR Ensembl; ENST00000525319; ENSP00000435464; ENSG00000142082. DR UCSC; uc010qvn.3; human. DR EuPathDB; HostDB:ENSG00000142082.14; -. DR HGNC; HGNC:14931; SIRT3. DR OpenTargets; ENSG00000142082; -. DR eggNOG; KOG2682; Eukaryota. DR eggNOG; COG0846; LUCA. DR GeneTree; ENSGT00940000159464; -. DR ChiTaRS; SIRT3; human. DR Proteomes; UP000005640; Chromosome 11. DR Bgee; ENSG00000142082; Expressed in 214 organ(s), highest expression level in anterior cingulate cortex. DR ExpressionAtlas; E9PK80; baseline and differential. DR GO; GO:0070403; F:NAD+ binding; IEA:UniProtKB-UniRule. DR GO; GO:0017136; F:NAD-dependent histone deacetylase activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule. DR Gene3D; 3.30.1600.10; -; 1. DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom. DR InterPro; IPR003000; Sirtuin. DR InterPro; IPR026591; Sirtuin_cat_small_dom_sf. DR InterPro; IPR017328; Sirtuin_class_I. DR InterPro; IPR026590; Ssirtuin_cat_dom. DR Pfam; PF02146; SIR2; 1. DR PIRSF; PIRSF037938; SIR2_euk; 1. DR SUPFAM; SSF52467; SSF52467; 1. DR PROSITE; PS50305; SIRTUIN; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Hydrolase {ECO:0000256|PIRNR:PIRNR037938}; KW Metal-binding {ECO:0000256|PIRNR:PIRNR037938, KW ECO:0000256|PIRSR:PIRSR037938-3}; KW NAD {ECO:0000256|PIRNR:PIRNR037938, ECO:0000256|PIRSR:PIRSR037938-2}; KW Proteomics identification {ECO:0000213|EPD:E9PK80, KW ECO:0000213|MaxQB:E9PK80, ECO:0000213|PeptideAtlas:E9PK80}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Zinc {ECO:0000256|PIRNR:PIRNR037938, ECO:0000256|PIRSR:PIRSR037938-3}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 318 NAD-dependent protein deacetylase. FT {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003244104. FT DOMAIN 45 301 Deacetylase sirtuin-type. FT {ECO:0000259|PROSITE:PS50305}. FT NP_BIND 65 69 NAD. {ECO:0000256|PIRSR:PIRSR037938-2}. FT NP_BIND 75 77 NAD. {ECO:0000256|PIRSR:PIRSR037938-2}. FT NP_BIND 147 150 NAD. {ECO:0000256|PIRSR:PIRSR037938-2}. FT NP_BIND 239 240 NAD. {ECO:0000256|PIRSR:PIRSR037938-2}. FT NP_BIND 263 265 NAD. {ECO:0000256|PIRSR:PIRSR037938-2}. FT ACT_SITE 167 167 Proton acceptor. FT {ECO:0000256|PIRSR:PIRSR037938-1}. FT METAL 175 175 Zinc. {ECO:0000256|PIRSR:PIRSR037938-3}. FT METAL 178 178 Zinc. {ECO:0000256|PIRSR:PIRSR037938-3}. FT METAL 199 199 Zinc. {ECO:0000256|PIRSR:PIRSR037938-3}. FT METAL 202 202 Zinc. {ECO:0000256|PIRSR:PIRSR037938-3}. FT BINDING 285 285 NAD; via amide nitrogen. FT {ECO:0000256|PIRSR:PIRSR037938-2}. SQ SEQUENCE 318 AA; 35148 MW; E11D06072D2B2521 CRC64; MAFWGWRAAA ALRLWGRVVE RVEAGGGVGP FQACGCRLVL GGRDDDVAEL IRARACQRVV VMVGAGISTP SGIPDFRSPG SGLYSNLQQY DLPYPEAIFE LPFFFHNPKP FFTLAKELYP GNYKPNVTHY FLRLLHDKGL LLRLYTQNID GLERVSGIPA SKLVEAHGTF ASATCTVCQR PFPGEDIRAD VMADRVPRCP VCTGVVKPDI VFFGEPLPQR FLLHVVDFPM ADLLLILGTS LEVEPFASLT EAVRSSVPRL LINRDLVGPL AWHPRSRDVA QLGDVVHGVE SLVELLGWTE EMRDLVQRET GKLDGPDK //