ID   E9PK76_HUMAN            Unreviewed;       116 AA.
AC   E9PK76;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 48.
DE   SubName: Full=Amyloid-like protein 2 {ECO:0000313|Ensembl:ENSP00000435470};
GN   Name=APLP2 {ECO:0000313|Ensembl:ENSP00000435470};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000435470, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000435470, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000435470}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP001183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP003041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PK76; -.
DR   SMR; E9PK76; -.
DR   jPOST; E9PK76; -.
DR   MaxQB; E9PK76; -.
DR   PeptideAtlas; E9PK76; -.
DR   Ensembl; ENST00000534582; ENSP00000435470; ENSG00000084234.
DR   UCSC; uc058jct.1; human.
DR   EuPathDB; HostDB:ENSG00000084234.16; -.
DR   HGNC; HGNC:598; APLP2.
DR   OpenTargets; ENSG00000084234; -.
DR   eggNOG; KOG3540; Eukaryota.
DR   eggNOG; ENOG410ZW2A; LUCA.
DR   GeneTree; ENSGT00940000158814; -.
DR   ChiTaRS; APLP2; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000084234; Expressed in 249 organ(s), highest expression level in pigmented layer of retina.
DR   ExpressionAtlas; E9PK76; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0008201; F:heparin binding; IEA:InterPro.
DR   Gene3D; 3.90.570.10; -; 1.
DR   InterPro; IPR008155; Amyloid_glyco.
DR   InterPro; IPR008154; Amyloid_glyco_extra.
DR   InterPro; IPR015849; Amyloid_glyco_heparin-bd.
DR   InterPro; IPR036454; Amyloid_glyco_heparin-bd_sf.
DR   PANTHER; PTHR23103; PTHR23103; 1.
DR   Pfam; PF02177; APP_N; 1.
DR   SMART; SM00006; A4_EXTRA; 1.
DR   SUPFAM; SSF56491; SSF56491; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E9PK76,
KW   ECO:0000213|MaxQB:E9PK76, ECO:0000213|PeptideAtlas:E9PK76};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    116       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245101.
FT   DOMAIN       42    116       A4_EXTRA. {ECO:0000259|SMART:SM00006}.
SQ   SEQUENCE   116 AA;  12279 MW;  AD128D4D84471C54 CRC64;
     MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIEALAAN AGTGFAVAEP QIAMFCGKLN
     MHVNIQTGKW EPDPTGTKSC FETKEEVLQY CQEMYPELQI TNSGWRCVRI TSTGTR
//