ID   E9PJL8_HUMAN            Unreviewed;       172 AA.
AC   E9PJL8;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 50.
DE   SubName: Full=Extracellular sulfatase Sulf-1 {ECO:0000313|Ensembl:ENSP00000431753};
DE   Flags: Fragment;
GN   Name=SULF1 {ECO:0000313|Ensembl:ENSP00000431753};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000431753, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000431753, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000431753}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC013746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC022790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PJL8; -.
DR   jPOST; E9PJL8; -.
DR   PeptideAtlas; E9PJL8; -.
DR   PRIDE; E9PJL8; -.
DR   Ensembl; ENST00000525999; ENSP00000431753; ENSG00000137573.
DR   UCSC; uc064nnn.1; human.
DR   EuPathDB; HostDB:ENSG00000137573.13; -.
DR   HGNC; HGNC:20391; SULF1.
DR   OpenTargets; ENSG00000137573; -.
DR   eggNOG; KOG3731; Eukaryota.
DR   eggNOG; COG3119; LUCA.
DR   GeneTree; ENSGT00940000157544; -.
DR   ChiTaRS; SULF1; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000137573; Expressed in 216 organ(s), highest expression level in pigmented layer of retina.
DR   ExpressionAtlas; E9PJL8; baseline and differential.
DR   GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:InterPro.
DR   Gene3D; 3.40.720.10; -; 1.
DR   InterPro; IPR017849; Alkaline_Pase-like_a/b/a.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; SSF53649; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E9PJL8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    172       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245258.
FT   DOMAIN       43    148       Sulfatase. {ECO:0000259|Pfam:PF00884}.
FT   NON_TER     172    172       {ECO:0000313|Ensembl:ENSP00000431753}.
SQ   SEQUENCE   172 AA;  19695 MW;  B7D6B45B4D07C65B CRC64;
     MKYSCCALVL AVLGTELLGS LCSTVRSPRF RGRIQQERKN IRPNIILVLT DDQDVELGSL
     QVMNKTRKIM EHGGATFINA FVTTPMCCPS RSSMLTGKYV HNHNVYTNNE NCSSPSWQAM
     HEPRTFAVYL NNTGYRTAFF GKYLNEYNGS YIPPGWREWL GLIKNSRFYN YT
//