ID   E9PJG7_HUMAN            Unreviewed;       467 AA.
AC   E9PJG7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   13-FEB-2019, entry version 64.
DE   SubName: Full=Beta-secretase 1 {ECO:0000313|Ensembl:ENSP00000431848};
GN   Name=BACE1 {ECO:0000313|Ensembl:ENSP00000431848};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000431848, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000431848, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000431848}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|PROSITE-ProRule:PRU01103,
CC       ECO:0000256|RuleBase:RU000454, ECO:0000256|SAAS:SAAS01079896}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01103}.
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DR   EMBL; AP000892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PJG7; -.
DR   jPOST; E9PJG7; -.
DR   PeptideAtlas; E9PJG7; -.
DR   PRIDE; E9PJG7; -.
DR   Ensembl; ENST00000528053; ENSP00000431848; ENSG00000186318.
DR   UCSC; uc058htj.1; human.
DR   EuPathDB; HostDB:ENSG00000186318.16; -.
DR   HGNC; HGNC:933; BACE1.
DR   OpenTargets; ENSG00000186318; -.
DR   GeneTree; ENSGT00940000157786; -.
DR   ChiTaRS; BACE1; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000186318; Expressed in 223 organ(s), highest expression level in C1 segment of cervical spinal cord.
DR   ExpressionAtlas; E9PJG7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd05473; beta_secretase_like; 1.
DR   Gene3D; 2.40.70.10; -; 3.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR009119; BACE.
DR   InterPro; IPR009120; BACE1.
DR   InterPro; IPR033874; Memapsin-like.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR13683; PTHR13683; 2.
DR   PANTHER; PTHR13683:SF245; PTHR13683:SF245; 2.
DR   Pfam; PF00026; Asp; 2.
DR   PRINTS; PR01816; BACE1.
DR   PRINTS; PR01815; BACEFAMILY.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; SSF50630; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   1: Evidence at protein level;
KW   Aspartyl protease {ECO:0000256|PROSITE-ProRule:PRU01103,
KW   ECO:0000256|RuleBase:RU000454};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01103,
KW   ECO:0000256|RuleBase:RU000454}; Membrane {ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01103,
KW   ECO:0000256|RuleBase:RU000454};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PJG7,
KW   ECO:0000213|PeptideAtlas:E9PJG7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    467       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003244096.
FT   TRANSMEM    424    444       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       75    382       Peptidase A1.
FT                                {ECO:0000259|PROSITE:PS51767}.
FT   ACT_SITE     93     93       {ECO:0000256|PROSITE-ProRule:PRU01103}.
FT   ACT_SITE    277    277       {ECO:0000256|PROSITE-ProRule:PRU01103}.
SQ   SEQUENCE   467 AA;  52080 MW;  25E46ECDABCC864C CRC64;
     MAQALPWLLL WMGAGVLPAH GTQHGIRLPL RSGLGGAPLG LRLPRETDEE PEEPGRRGSF
     VEMVDNLRGK SGQGYYVEMT VGSPPQTLNI LVDTGSSNFA VGAAPHPFLH RYYQRQLSST
     YRDLRKGVYV PYTQGKWEGE LGTDLVSIPH GPNVTVRANI AAITESDKFF INGSNWEGIL
     GLAYAEIARP DDSLEPFFDS LVKQTHVPNL FSLQLCGAGF PLNQSEVLAS VGGSMIIGGI
     DHSLYTGSLW YTPIRREWYY EVIIVRVEIN GQDLKMDCKE TEKFPDGFWL GEQLVCWQAG
     TTPWNIFPVI SLYLMGEVTN QSFRITILPQ QYLRPVEDVA TSQDDCYKFA ISQSSTGTVM
     GAVIMEGFYV VFDRARKRIG FAVSACHVHD EFRTAAVEGP FVTLDMEDCG YNIPQTDEST
     LMTIAYVMAA ICALFMLPLC LMVCQWRCLR CLRQQHDDFA DDISLLK
//