ID   E9PIZ2_HUMAN            Unreviewed;       690 AA.
AC   E9PIZ2;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 61.
DE   SubName: Full=LARGE xylosyl- and glucuronyltransferase 2 {ECO:0000313|Ensembl:ENSP00000431932};
GN   Name=LARGE2 {ECO:0000313|Ensembl:ENSP00000431932};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000431932, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000431932, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000431932}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC068385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001287651.1; NM_001300722.1.
DR   RefSeq; XP_006718203.1; XM_006718140.1.
DR   UniGene; Hs.86543; -.
DR   ProteinModelPortal; E9PIZ2; -.
DR   jPOST; E9PIZ2; -.
DR   PeptideAtlas; E9PIZ2; -.
DR   PRIDE; E9PIZ2; -.
DR   Ensembl; ENST00000529052; ENSP00000431932; ENSG00000165905.
DR   GeneID; 120071; -.
DR   UCSC; uc001nbw.2; human.
DR   CTD; 120071; -.
DR   EuPathDB; HostDB:ENSG00000165905.16; -.
DR   HGNC; HGNC:16522; LARGE2.
DR   OpenTargets; ENSG00000165905; -.
DR   GeneTree; ENSGT00940000158758; -.
DR   OrthoDB; 729091at2759; -.
DR   GenomeRNAi; 120071; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000165905; Expressed in 125 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; E9PIZ2; baseline and differential.
DR   GO; GO:0016757; F:transferase activity, transferring glycosyl groups; IEA:InterPro.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR002495; Glyco_trans_8.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF01501; Glyco_transf_8; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E9PIZ2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00469293}.
FT   SIGNAL        1     36       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        37    690       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003244089.
SQ   SEQUENCE   690 AA;  78701 MW;  AD778D48C487C7C2 CRC64;
     MLPRGRPRAL GAAALLLLLL LLGFLLFDGR LRRAAALDGD PGAGPGDHNR SDCGPQPPPP
     PKCELLHVAI VCAGHNSSRD VITLVKSMLF YRKNPLHLHL VTDAVARNIL ETLFHTWMVP
     AVRVSFYHAD QLKPQVSWIP NKHYSGLYGL MKLVLPSALP AELARVIVLD TDVTFASDIS
     ELWALFAHFS DTQAIGLVEN QSDWYLGNLW KNHRPWPALG RGFNTGVILL RLDRLRQAGW
     EQMWRLTARR ELLSLPATSL ADQDIFNAVI KEHPGLVQRL PCVWNVQLSD HTLAERCYSE
     ASDLKVIHWN SPKKLRVKNK HVEFFRNFYL TFLEYDGNLL RRELFVCPSQ PPPGAEQLQQ
     ALAQLDEEDP CFEFRQQQLT VHRVHVTFLP HEPPPPRPHD VTLVAQLSMD RLQMLEALCR
     HWPGPMSLAL YLTDAEAQQF LHFVEASPVL AARQDVAYHV VYREGPLYPV NQLRNVALAQ
     ALTPYVFLSD IDFLPAYSLY DYLRASIEQL GLGSRRKAAL VVPAFETLRY RFSFPHSKVE
     LLALLDAGTL YTFRYHEWPR GHAPTDYARW REAQAPYRVQ WAANYEPYVV VPRDCPRYDP
     RFVGFGWNKV AHIVELDAQE YELLVLPEAF TIHLPHAPSL DISRFRSSPT YRDCLQALKD
     EFHQDLSRHH GAAALKYLPA LQQPQSPARG
//