ID   E9PIS1_HUMAN            Unreviewed;        55 AA.
AC   E9PIS1;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   SubName: Full=Cathepsin B {ECO:0000313|Ensembl:ENSP00000433929};
DE   Flags: Fragment;
GN   Name=CTSB {ECO:0000313|Ensembl:ENSP00000433929};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000433929, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000433929, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000433929}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC025857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC069185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; E9PIS1; -.
DR   PeptideAtlas; E9PIS1; -.
DR   PRIDE; E9PIS1; -.
DR   Ensembl; ENST00000528965; ENSP00000433929; ENSG00000164733.
DR   UCSC; uc064kil.1; human.
DR   EuPathDB; HostDB:ENSG00000164733.20; -.
DR   HGNC; HGNC:2527; CTSB.
DR   OpenTargets; ENSG00000164733; -.
DR   eggNOG; KOG1543; Eukaryota.
DR   eggNOG; COG4870; LUCA.
DR   GeneTree; ENSGT00940000158680; -.
DR   ChiTaRS; CTSB; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000164733; Expressed in 232 organ(s), highest expression level in thyroid gland.
DR   ExpressionAtlas; E9PIS1; baseline and differential.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:InterPro.
DR   InterPro; IPR012599; Propeptide_C1A.
DR   Pfam; PF08127; Propeptide_C1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PIS1,
KW   ECO:0000213|PeptideAtlas:E9PIS1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18     55       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003244085.
FT   DOMAIN       26     55       Propeptide_C1.
FT                                {ECO:0000259|Pfam:PF08127}.
FT   NON_TER      55     55       {ECO:0000313|Ensembl:ENSP00000433929}.
SQ   SEQUENCE   55 AA;  6475 MW;  51E5E393AD8ABCC7 CRC64;
     MWQLWASLCC LLVLANARSR PSFHPLSDEL VNYVNKRNTT WQAGHNFYNV DMSYL
//