ID   E9PIF0_HUMAN            Unreviewed;       157 AA.
AC   E9PIF0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   05-DEC-2018, entry version 56.
DE   SubName: Full=Relaxin receptor 1 {ECO:0000313|Ensembl:ENSP00000432036};
GN   Name=RXFP1 {ECO:0000313|Ensembl:ENSP00000432036};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000432036, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000432036, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000432036}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR   EMBL; AC019341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC107056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC107219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC121161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC125489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PIF0; -.
DR   PRIDE; E9PIF0; -.
DR   Ensembl; ENST00000342048; ENSP00000432036; ENSG00000171509.
DR   UCSC; uc063apu.1; human.
DR   EuPathDB; HostDB:ENSG00000171509.15; -.
DR   HGNC; HGNC:19718; RXFP1.
DR   OpenTargets; ENSG00000171509; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   eggNOG; KOG2087; Eukaryota.
DR   eggNOG; COG4886; LUCA.
DR   GeneTree; ENSGT00940000158241; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000171509; Expressed in 94 organ(s), highest expression level in decidua.
DR   ExpressionAtlas; E9PIF0; baseline and differential.
DR   CDD; cd00112; LDLa; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF00057; Ldl_recept_a; 1.
DR   SMART; SM00192; LDLa; 1.
DR   SUPFAM; SSF57424; SSF57424; 1.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124,
KW   ECO:0000256|SAAS:SAAS01050632};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    157       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245053.
FT   DISULFID     47     62       {ECO:0000256|PROSITE-ProRule:PRU00124}.
SQ   SEQUENCE   157 AA;  17528 MW;  A7422C44AC3216E7 CRC64;
     MTSGSVFFYI LIFGKYFSHG GGQDVKCSLG YFPCGNITKC LPQLLHCNGV DDCGNQADED
     NCGDNNGWSL QFDKYFASYY KMTSQYPFEA ETPECLVGSV PVQCLCQGLE LDCDETNLRA
     VPSVSSNVTA MSLQWNLIRK LPPDCFKNYH DLQKLTL
//