ID   E9PIE6_HUMAN            Unreviewed;       167 AA.
AC   E9PIE6;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   05-DEC-2018, entry version 43.
DE   SubName: Full=Transmembrane protein 25 {ECO:0000313|Ensembl:ENSP00000432040};
DE   Flags: Fragment;
GN   Name=TMEM25 {ECO:0000313|Ensembl:ENSP00000432040};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000432040, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000432040, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000432040}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP000941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PIE6; -.
DR   PeptideAtlas; E9PIE6; -.
DR   PRIDE; E9PIE6; -.
DR   Ensembl; ENST00000528373; ENSP00000432040; ENSG00000149582.
DR   UCSC; uc058hyw.1; human.
DR   EuPathDB; HostDB:ENSG00000149582.15; -.
DR   HGNC; HGNC:25890; TMEM25.
DR   OpenTargets; ENSG00000149582; -.
DR   eggNOG; ENOG410IF2Y; Eukaryota.
DR   eggNOG; ENOG410ZNWF; LUCA.
DR   GeneTree; ENSGT00940000154178; -.
DR   ChiTaRS; TMEM25; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149582; Expressed in 150 organ(s), highest expression level in cerebellum.
DR   ExpressionAtlas; E9PIE6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF08205; C2-set_2; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00504776};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E9PIE6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    167       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003244078.
FT   TRANSMEM    138    164       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       30    123       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   NON_TER     167    167       {ECO:0000313|Ensembl:ENSP00000432040}.
SQ   SEQUENCE   167 AA;  17707 MW;  287DB8E2DEE65327 CRC64;
     MALPPGPAAL RHTLLLLPAL LSSGWGELEP QIDGQTWAER ALRENERHAF TCRVAGGPGT
     PRLAWYLDGQ LQEASTSRLL SVGGEAFSGG TSTFTVTAHR AQHELNCSLQ DPRSGRSANA
     SVILNVQWLL ATRVEVPLLG IVVAAGLALG TLVGFSTLVA CLVCRKE
//