ID   E9PI80_HUMAN            Unreviewed;       119 AA.
AC   E9PI80;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 50.
DE   SubName: Full=CD59 glycoprotein {ECO:0000313|Ensembl:ENSP00000436737};
GN   Name=CD59 {ECO:0000313|Ensembl:ENSP00000436737};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436737, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000436737, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000436737}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [4] {ECO:0000313|Ensembl:ENSP00000495784}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AL049629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PI80; -.
DR   jPOST; E9PI80; -.
DR   MaxQB; E9PI80; -.
DR   PeptideAtlas; E9PI80; -.
DR   PRIDE; E9PI80; -.
DR   Ensembl; ENST00000533403; ENSP00000436737; ENSG00000085063.
DR   Ensembl; ENST00000643183; ENSP00000495784; ENSG00000085063.
DR   UCSC; uc058afq.1; human.
DR   EuPathDB; HostDB:ENSG00000085063.14; -.
DR   HGNC; HGNC:1689; CD59.
DR   OpenTargets; ENSG00000085063; -.
DR   eggNOG; ENOG410J39P; Eukaryota.
DR   eggNOG; ENOG410ZEQP; LUCA.
DR   GeneTree; ENSGT00390000016309; -.
DR   ChiTaRS; CD59; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000085063; Expressed in 234 organ(s), highest expression level in chorionic villus.
DR   ExpressionAtlas; E9PI80; baseline and differential.
DR   GO; GO:0001971; P:negative regulation of activation of membrane attack complex; IEA:InterPro.
DR   InterPro; IPR027101; CD59_glyco.
DR   PANTHER; PTHR10036:SF9; PTHR10036:SF9; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    119       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245047.
SQ   SEQUENCE   119 AA;  13041 MW;  7C54C976D35BE7F5 CRC64;
     MGIQGGSVLF GLLLVLAVFC HSGHSLQCYN CPNPTADCKT AVNCSSDFDA CLITKAELGY
     HYVAQAGRRQ SSHFSLLKCW DYRCEPSHWP HCPYFNWGYK CITSVGSLSI AISTTSQPA
//