ID   E9PI30_HUMAN            Unreviewed;       364 AA.
AC   E9PI30;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   05-DEC-2018, entry version 51.
DE   SubName: Full=Cathepsin W {ECO:0000313|Ensembl:ENSP00000436568};
GN   Name=CTSW {ECO:0000313|Ensembl:ENSP00000436568};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436568, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000436568, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000436568}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|RuleBase:RU362133, ECO:0000256|SAAS:SAAS01048375}.
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DR   EMBL; AP001201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PI30; -.
DR   PeptideAtlas; E9PI30; -.
DR   PRIDE; E9PI30; -.
DR   Ensembl; ENST00000528419; ENSP00000436568; ENSG00000172543.
DR   UCSC; uc058drg.1; human.
DR   EuPathDB; HostDB:ENSG00000172543.7; -.
DR   HGNC; HGNC:2546; CTSW.
DR   OpenTargets; ENSG00000172543; -.
DR   eggNOG; KOG1542; Eukaryota.
DR   eggNOG; COG4870; LUCA.
DR   GeneTree; ENSGT00940000161630; -.
DR   ChiTaRS; CTSW; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000172543; Expressed in 112 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; E9PI30; baseline and differential.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR   CDD; cd02248; Peptidase_C1A; 1.
DR   InterPro; IPR033158; Cathepsin_W.
DR   InterPro; IPR038765; Papain_like_cys_pep_sf.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR039417; Peptidase_C1A_papain-like.
DR   InterPro; IPR013201; Prot_inhib_I29.
DR   PANTHER; PTHR12411; PTHR12411; 1.
DR   PANTHER; PTHR12411:SF101; PTHR12411:SF101; 1.
DR   Pfam; PF08246; Inhibitor_I29; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00848; Inhibitor_I29; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E9PI30,
KW   ECO:0000213|MaxQB:E9PI30, ECO:0000213|PeptideAtlas:E9PI30};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU362133}.
FT   SIGNAL        1     21       {ECO:0000256|RuleBase:RU362133}.
FT   CHAIN        22    364       {ECO:0000256|RuleBase:RU362133}.
FT                                /FTId=PRO_5005397589.
FT   DOMAIN       42     99       Inhibitor_I29.
FT                                {ECO:0000259|SMART:SM00848}.
FT   DOMAIN      128    345       Pept_C1. {ECO:0000259|SMART:SM00645}.
SQ   SEQUENCE   364 AA;  40750 MW;  FD07CB957DB0BACA CRC64;
     MALTAHPSCL LALLVAGLAQ GIRGPLRAQD LGPQPLELKE AFKLFQIQFN RSYLSPEEHA
     HRLDIFAHNL AQAQRLQEED LGTAEFGVTP FSDLTEEEFG QLYGYRRAAG GVPSMGREIR
     SEEPEESVPF SCDWRKVASA ISPIKDQKNC NCCWAMAAAG NIETLWRISF WDFVDVSVQE
     LLDCGRCGDG CHGGFVWDAF ITVLNNSGLA SEKDYPFQGK VRAHRCHPKK YQKVAWIQDF
     IMLQNNEHRI AQYLATYGPI TVTINMKPLQ LYRKGVIKAT PTTCDPQLVD HSVLLVGFGS
     VKSEEGIWAE TVSSQSQPQP PHPTPYWILK NSWGAQWGEK VSVIYWGRGQ GRTGLFPPSR
     PYVP
//