ID   E9PHZ3_HUMAN            Unreviewed;       111 AA.
AC   E9PHZ3;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 47.
DE   RecName: Full=FXYD domain-containing ion transport regulator {ECO:0000256|RuleBase:RU364131};
GN   Name=FXYD6 {ECO:0000313|Ensembl:ENSP00000436629};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436629, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000436629, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000436629}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the FXYD family.
CC       {ECO:0000256|RuleBase:RU364131}.
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DR   EMBL; AP000757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PHZ3; -.
DR   PeptideAtlas; E9PHZ3; -.
DR   PRIDE; E9PHZ3; -.
DR   Ensembl; ENST00000529335; ENSP00000436629; ENSG00000137726.
DR   UCSC; uc058hut.1; human.
DR   EuPathDB; HostDB:ENSG00000137726.16; -.
DR   HGNC; HGNC:4030; FXYD6.
DR   OpenTargets; ENSG00000137726; -.
DR   eggNOG; ENOG410IZ88; Eukaryota.
DR   eggNOG; ENOG410YUN8; LUCA.
DR   GeneTree; ENSGT00940000153062; -.
DR   PhylomeDB; E9PHZ3; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000137726; Expressed in 219 organ(s), highest expression level in cerebellar vermis.
DR   ExpressionAtlas; E9PHZ3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0043269; P:regulation of ion transport; IEA:InterPro.
DR   InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR   Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR   ProDom; PD005989; PD005989; 1.
DR   PROSITE; PS01310; FXYD; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ion transport {ECO:0000256|RuleBase:RU364131};
KW   Membrane {ECO:0000256|RuleBase:RU364131};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU364131};
KW   Transmembrane {ECO:0000256|RuleBase:RU364131};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU364131};
KW   Transport {ECO:0000256|RuleBase:RU364131}.
FT   SIGNAL        1     18       {ECO:0000256|RuleBase:RU364131}.
FT   CHAIN        19    111       FXYD domain-containing ion transport
FT                                regulator.
FT                                {ECO:0000256|RuleBase:RU364131}.
FT                                /FTId=PRO_5011329990.
FT   TRANSMEM     36     56       Helical. {ECO:0000256|RuleBase:RU364131}.
SQ   SEQUENCE   111 AA;  12490 MW;  4B3045D6FF5E9B74 CRC64;
     MELVLVFLCS LLAPMVLASA EKEKEMDPFH YDYQTLRIGG LVFAVVLFSV GILLILSRRC
     KCSFNQKPRA PGDEEAQQQS PRKQRTEVQP SGGSLWNLRR LLEPLDANVD A
//