ID   E9PHY3_HUMAN            Unreviewed;       183 AA.
AC   E9PHY3;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 39.
DE   SubName: Full=Dickkopf-related protein 3 {ECO:0000313|Ensembl:ENSP00000436645};
DE   Flags: Fragment;
GN   Name=DKK3 {ECO:0000313|Ensembl:ENSP00000436645};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436645, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000436645, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000436645}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC124276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PHY3; -.
DR   jPOST; E9PHY3; -.
DR   MaxQB; E9PHY3; -.
DR   PeptideAtlas; E9PHY3; -.
DR   PRIDE; E9PHY3; -.
DR   Ensembl; ENST00000534511; ENSP00000436645; ENSG00000050165.
DR   UCSC; uc057zdp.1; human.
DR   EuPathDB; HostDB:ENSG00000050165.17; -.
DR   HGNC; HGNC:2893; DKK3.
DR   OpenTargets; ENSG00000050165; -.
DR   GeneTree; ENSGT00390000000221; -.
DR   ChiTaRS; DKK3; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000050165; Expressed in 230 organ(s), highest expression level in primary visual cortex.
DR   ExpressionAtlas; E9PHY3; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0007275; P:multicellular organism development; IEA:InterPro.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR   InterPro; IPR006796; Dickkopf_N.
DR   InterPro; IPR039863; DKK-like.
DR   PANTHER; PTHR12113; PTHR12113; 2.
DR   Pfam; PF04706; Dickkopf_N; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PHY3,
KW   ECO:0000213|PeptideAtlas:E9PHY3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    183       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245202.
FT   DOMAIN      118    168       Dickkopf_N. {ECO:0000259|Pfam:PF04706}.
FT   COILED       40     78       {ECO:0000256|SAM:Coils}.
FT   NON_TER     183    183       {ECO:0000313|Ensembl:ENSP00000436645}.
SQ   SEQUENCE   183 AA;  20037 MW;  7DE79D1DF0CB69D8 CRC64;
     MQRLGATLLC LLLAAAVPTA PAPAPTATSA PVKPGPALSY PQEEATLNEM FREVEELMED
     TQHKLRSAVE EMEAEEAAAK ASSEVNLANL PPSYHNETNT DTKVGNNTIH VHREIHKECI
     IDEDCGPSMY CQFASFQYTC QPCRGQRMLC TRDSECCGDQ LCVWGHCTKM ATRGSNGTIC
     DNQ
//