ID   E9PHY1_HUMAN            Unreviewed;       471 AA.
AC   E9PHY1;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 56.
DE   SubName: Full=Low-density lipoprotein receptor-related protein 5 {ECO:0000313|Ensembl:ENSP00000436652};
GN   Name=LRP5 {ECO:0000313|Ensembl:ENSP00000436652};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436652, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000436652, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000436652}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AP000807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP002813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PHY1; -.
DR   jPOST; E9PHY1; -.
DR   MaxQB; E9PHY1; -.
DR   PeptideAtlas; E9PHY1; -.
DR   PRIDE; E9PHY1; -.
DR   Ensembl; ENST00000529993; ENSP00000436652; ENSG00000162337.
DR   UCSC; uc058enc.1; human.
DR   EuPathDB; HostDB:ENSG00000162337.11; -.
DR   HGNC; HGNC:6697; LRP5.
DR   OpenTargets; ENSG00000162337; -.
DR   eggNOG; ENOG410IPT4; Eukaryota.
DR   eggNOG; ENOG410XSY5; LUCA.
DR   GeneTree; ENSGT00940000156574; -.
DR   ChiTaRS; LRP5; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000162337; Expressed in 171 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; E9PHY1; baseline and differential.
DR   Gene3D; 2.120.10.30; -; 2.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   Pfam; PF00058; Ldl_recept_b; 5.
DR   SMART; SM00135; LY; 7.
DR   PROSITE; PS51120; LDLRB; 7.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E9PHY1,
KW   ECO:0000213|MaxQB:E9PHY1, ECO:0000213|PeptideAtlas:E9PHY1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    471       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245039.
FT   REPEAT       75    119       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      120    162       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      163    206       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      207    249       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      250    290       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      385    427       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      428    470       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
SQ   SEQUENCE   471 AA;  52432 MW;  9457467F2F09FCC9 CRC64;
     MEAAPPGPPW PLLLLLLLLL ALCGCPAPAA ASPLLLFANR RDVRLVDAGG VKLESTIVVS
     GLEDAAAVDF QFSKGAVYWT DVSEEAIKQT YLNQTGAAVQ NVVISGLVSP DGLACDWVGK
     KLYWTDSETN RIEVANLNGT SRKVLFWQDL DQPRAIALDP AHGYMYWTDW GETPRIERAG
     MDGSTRKIIV DSDIYWPNGL TIDLEEQKLY WADAKLSFIH RANLDGSFRQ KVVEGSLTHP
     FALTLSGDTL YWTDWQTRSI HACNKRTGGK RKEILSALYS PMDIQVLSQE RQPFFHTRCE
     EDNGGCSHLC LLSPSEPFYT CACPTGVQLQ DNGRTCKAGA EEVLLLARRT DLRRISLDTP
     DFTDIVLQVD DIRHAIAIDY DPLEGYVYWT DDEVRAIRRA YLDGSGAQTL VNTEINDPDG
     IAVDWVARNL YWTDTGTDRI EVTRLNGTSR KILVSEDLDE PRAIALHPVM G
//