ID   E9PHY0_HUMAN            Unreviewed;       360 AA.
AC   E9PHY0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=Lysosomal acid phosphatase {ECO:0000313|Ensembl:ENSP00000436658};
GN   Name=ACP2 {ECO:0000313|Ensembl:ENSP00000436658};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000436658, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000436658, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000436658}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC       {ECO:0000256|SAAS:SAAS00793915}.
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DR   EMBL; AC018410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001289420.1; NM_001302491.1.
DR   UniGene; Hs.532492; -.
DR   ProteinModelPortal; E9PHY0; -.
DR   jPOST; E9PHY0; -.
DR   MaxQB; E9PHY0; -.
DR   PeptideAtlas; E9PHY0; -.
DR   PRIDE; E9PHY0; -.
DR   Ensembl; ENST00000529444; ENSP00000436658; ENSG00000134575.
DR   GeneID; 53; -.
DR   UCSC; uc010rhg.3; human.
DR   CTD; 53; -.
DR   EuPathDB; HostDB:ENSG00000134575.9; -.
DR   HGNC; HGNC:123; ACP2.
DR   OpenTargets; ENSG00000134575; -.
DR   eggNOG; KOG3720; Eukaryota.
DR   eggNOG; ENOG410ZVBQ; LUCA.
DR   GeneTree; ENSGT00940000158446; -.
DR   OrthoDB; 1221585at2759; -.
DR   ChiTaRS; ACP2; human.
DR   GenomeRNAi; 53; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000134575; Expressed in 218 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; E9PHY0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd07061; HP_HAP_like; 1.
DR   Gene3D; 3.40.50.1240; -; 2.
DR   InterPro; IPR033379; Acid_Pase_AS.
DR   InterPro; IPR000560; His_Pase_clade-2.
DR   InterPro; IPR029033; His_PPase_superfam.
DR   Pfam; PF00328; His_Phos_2; 2.
DR   SUPFAM; SSF53254; SSF53254; 1.
DR   PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
DR   PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:E9PHY0,
KW   ECO:0000213|MaxQB:E9PHY0, ECO:0000213|PeptideAtlas:E9PHY0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31    360       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242846.
FT   TRANSMEM    318    341       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   360 AA;  40990 MW;  3EB3A21AF99FF6A4 CRC64;
     MAGKRSGWSR AALLQLLLGV NLVVMPPTRA RSLRFVTLLY RHGDRSPVKT YPKDPYQEEE
     WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV YVRSTDFDRT LMSAEANLAG
     LFPPNGMQRF NPNISWQPIP VHTVPITEDR QTHGLRLPPW ASPQTMQRLS RLKDFSFRFL
     FGIYQQAEKA RLQGGVLLAQ IRKNLTLMAT TSQLPKLLVY SAHDTTLVAL QMALDVYNGE
     QAPYASCHIF ELYQEDSGNF SVEMYFRNES DKAPWPLSLP GCPHRCPLQD FLRLTEPVVP
     KDWQQECQLA SGPADTEVIV ALAVCGSILF LLIVLLLTVL FRMQAQPPGY RHVADGEDHA
//