ID   E9PHW4_HUMAN            Unreviewed;       341 AA.
AC   E9PHW4;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   13-FEB-2019, entry version 69.
DE   SubName: Full=Fibrillin-2 {ECO:0000313|Ensembl:ENSP00000424753};
GN   Name=FBN2 {ECO:0000313|Ensembl:ENSP00000424753};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000424753, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000424753, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000424753}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC025169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC034235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC113387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC114276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PHW4; -.
DR   SMR; E9PHW4; -.
DR   jPOST; E9PHW4; -.
DR   MaxQB; E9PHW4; -.
DR   PeptideAtlas; E9PHW4; -.
DR   PRIDE; E9PHW4; -.
DR   Ensembl; ENST00000502468; ENSP00000424753; ENSG00000138829.
DR   UCSC; uc003kuw.6; human.
DR   EuPathDB; HostDB:ENSG00000138829.10; -.
DR   HGNC; HGNC:3604; FBN2.
DR   OpenTargets; ENSG00000138829; -.
DR   eggNOG; ENOG410IR7H; Eukaryota.
DR   eggNOG; ENOG410XSTY; LUCA.
DR   GeneTree; ENSGT00940000153951; -.
DR   ChiTaRS; FBN2; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000138829; Expressed in 146 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; E9PHW4; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR   Gene3D; 3.90.290.10; -; 1.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR011398; FBN.
DR   InterPro; IPR040872; Fibrillin_U_N.
DR   InterPro; IPR017878; TB_dom.
DR   InterPro; IPR036773; TB_dom_sf.
DR   PANTHER; PTHR24039; PTHR24039; 1.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF18193; Fibrillin_U_N; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00179; EGF_CA; 1.
DR   SUPFAM; SSF57581; SSF57581; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS51364; TB; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677};
KW   Proteomics identification {ECO:0000213|EPD:E9PHW4,
KW   ECO:0000213|MaxQB:E9PHW4, ECO:0000213|PeptideAtlas:E9PHW4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29    341       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242805.
FT   DOMAIN      176    208       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      214    257       TB. {ECO:0000259|PROSITE:PS51364}.
FT   DOMAIN      276    317       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DISULFID    180    190       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    198    207       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   341 AA;  36796 MW;  DA2230C8DBB78425 CRC64;
     MGRRRRLCLQ LYFLWLGCVV LWAQGTAGQP QPPPPKPPRP QPPPQQVRSA TAGSEGGFLA
     PEYREEGAAV ASRVRRRGQQ DVLRGPNVCG SRFHSYCCPG WKTLPGGNQC IVPICRNSCG
     DGFCSRPNMC TCSSGQISST CGSKSIQQCS VRCMNGGTCA DDHCQCQKGY IGTYCGQPVC
     ENGCQNGGRC IGPNRCACVY GFTGPQCERD YRTGPCFTQV NNQMCQGQLT GIVCTKTLCC
     ATIGRAWGHP CEMCPAQPQP CRRGFIPNIR TGACQDVDEC QAIPGICQGG NCINTVGSFE
     CRCPAGHKQS ETTQKCEVHV DKAQAGARCP CVILPSRLYL R
//