ID E9PHI0_HUMAN Unreviewed; 502 AA. AC E9PHI0; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 16-JAN-2019, entry version 56. DE SubName: Full=Adhesion G-protein-coupled receptor G7 {ECO:0000313|Ensembl:ENSP00000419788}; GN Name=ADGRG7 {ECO:0000313|Ensembl:ENSP00000419788}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000419788, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000419788, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., RA Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., RA Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., RA Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000419788} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. CC {ECO:0000256|SAAS:SAAS01128750}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC069223; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF457660; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001295291.1; NM_001308362.1. DR UniGene; Hs.334511; -. DR ProteinModelPortal; E9PHI0; -. DR PeptideAtlas; E9PHI0; -. DR PRIDE; E9PHI0; -. DR Ensembl; ENST00000475887; ENSP00000419788; ENSG00000144820. DR GeneID; 84873; -. DR UCSC; uc062lzq.1; human. DR CTD; 84873; -. DR EuPathDB; HostDB:ENSG00000144820.7; -. DR HGNC; HGNC:19241; ADGRG7. DR OpenTargets; ENSG00000144820; -. DR eggNOG; KOG4193; Eukaryota. DR eggNOG; ENOG410XSD2; LUCA. DR GeneTree; ENSGT00940000159169; -. DR OrthoDB; 349194at2759; -. DR ChiTaRS; ADGRG7; human. DR GenomeRNAi; 84873; -. DR Proteomes; UP000005640; Chromosome 3. DR Bgee; ENSG00000144820; Expressed in 74 organ(s), highest expression level in intestine. DR ExpressionAtlas; E9PHI0; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro. DR InterPro; IPR017981; GPCR_2-like. DR InterPro; IPR000832; GPCR_2_secretin-like. DR InterPro; IPR000203; GPS. DR Pfam; PF00002; 7tm_2; 1. DR Pfam; PF01825; GPS; 1. DR PRINTS; PR00249; GPCRSECRETIN. DR SMART; SM00303; GPS; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. DR PROSITE; PS50221; GPS; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00501090, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00501090, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00501090, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 502 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003245033. FT TRANSMEM 141 163 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 175 194 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 237 259 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 271 295 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 329 357 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 378 396 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 402 425 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 85 132 GPS. {ECO:0000259|PROSITE:PS50221}. FT DOMAIN 139 429 G_PROTEIN_RECEP_F2_4. FT {ECO:0000259|PROSITE:PS50261}. SQ SEQUENCE 502 AA; 57425 MW; 2C3289FE13778749 CRC64; MPVKMLFKEL LLLLMMMPLQ HYTKTCGFVV YQNDKLFQSK TFTAKSDFSQ KIISSKTDEN EQDQSASVDM VFSPKYNQKE FQLYSYACVY WNLSAKDWDT YGCQKDKGTD GFLRCRCNHT TNFAVLMTFK KDYQYPKSLD ILSNVGCALS VTGLALTVIF QIVTRKVRKT SVTWVLVNLC ISMLIFNLLF VFGIENSNKN LQTSDGDINN IDFDNNDIPR TDTINIPNPM CTAIAALLHY FLLVTFTWNA LSAAQLYYLL IRTMKPLPRH FILFISLIGW GVPAIVVAIT VGVIYSQNGN NPQWELDYRQ EKICWLAIPE PNGVIKSPLL WSFIVPVTII LISNVVMFIT ISIKVLWKNN QNLTSTKKVS SMKKIVSTLS VAVVFGITWI LAYLMLVNDD SIRIVFSYIF CLFNTTQGLQ IFILYTVRTK VFQSEASKVL MLLSSIGRRK SLPSVTRPRL RVKMYNFLRS LPTLHERFRL LETSPSTEEI TLSESDNAKE SI //