ID   E9PGI0_HUMAN            Unreviewed;       395 AA.
AC   E9PGI0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 47.
DE   SubName: Full=Arylsulfatase K {ECO:0000313|Ensembl:ENSP00000423636};
GN   Name=ARSK {ECO:0000313|Ensembl:ENSP00000423636};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000423636, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000423636, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000423636}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC008547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PGI0; -.
DR   EPD; E9PGI0; -.
DR   jPOST; E9PGI0; -.
DR   MaxQB; E9PGI0; -.
DR   PeptideAtlas; E9PGI0; -.
DR   PRIDE; E9PGI0; -.
DR   Ensembl; ENST00000504873; ENSP00000423636; ENSG00000164291.
DR   UCSC; uc063fmk.1; human.
DR   EuPathDB; HostDB:ENSG00000164291.16; -.
DR   HGNC; HGNC:25239; ARSK.
DR   OpenTargets; ENSG00000164291; -.
DR   eggNOG; KOG3731; Eukaryota.
DR   eggNOG; COG3119; LUCA.
DR   GeneTree; ENSGT00940000158982; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000164291; Expressed in 196 organ(s), highest expression level in prostate gland.
DR   ExpressionAtlas; E9PGI0; baseline and differential.
DR   GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:InterPro.
DR   Gene3D; 3.40.720.10; -; 1.
DR   InterPro; IPR017849; Alkaline_Pase-like_a/b/a.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR000917; Sulfatase_N.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; SSF53649; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PGI0,
KW   ECO:0000213|PeptideAtlas:E9PGI0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     15       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        16    395       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5013220545.
FT   DOMAIN       32    366       Sulfatase. {ECO:0000259|Pfam:PF00884}.
SQ   SEQUENCE   395 AA;  44959 MW;  E5DBFACED86AA92A CRC64;
     MLLLWVSVVA ALALAVLAPG AGEQRRRAAK APNVVLVVSD SFDGRLTFHP GSQVVKLPFI
     NFMKTRGTSF LNAYTNSPIC CPSRAAMWSG LFTHLTESWN NFKGLDPNYT TWMDVMERHG
     YRTQKFGKLD YTSGHHSISN RVEAWTRDVA FLLRQEGRPM VNLIRNRTKV RVMERDWQNT
     DKAVNWLRKE AINYTEPFVI YLGLNLPHPY PSPSSGENFG SSTFHTSLYW LEKVSHDAIK
     IPKWSPLSEM HPVDYYSSYT KNCTGRFTKK EIKNIRAFYY AMCAETDAML GEIILALHQL
     DLLQKTIVIY SSDHGELAME HRQFYKMSMY EASAHVPLLM MGPGIKAGLQ VSNVVSLVDI
     YPTMLDEKTE VEISKLLAEV HMASGILLEF LCLRT
//