ID   E9PG08_HUMAN            Unreviewed;       317 AA.
AC   E9PG08;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   SubName: Full=Fetuin-B {ECO:0000313|Ensembl:ENSP00000371569};
GN   Name=FETUB {ECO:0000313|Ensembl:ENSP00000371569};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000371569, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000371569, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000371569}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AC068631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001295008.1; NM_001308079.1.
DR   UniGene; Hs.81073; -.
DR   ProteinModelPortal; E9PG08; -.
DR   SMR; E9PG08; -.
DR   PeptideAtlas; E9PG08; -.
DR   PRIDE; E9PG08; -.
DR   Ensembl; ENST00000382134; ENSP00000371569; ENSG00000090512.
DR   GeneID; 26998; -.
DR   UCSC; uc003fqp.5; human.
DR   CTD; 26998; -.
DR   EuPathDB; HostDB:ENSG00000090512.11; -.
DR   HGNC; HGNC:3658; FETUB.
DR   OpenTargets; ENSG00000090512; -.
DR   GeneTree; ENSGT00940000153911; -.
DR   OrthoDB; 1254847at2759; -.
DR   GenomeRNAi; 26998; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000090512; Expressed in 59 organ(s), highest expression level in liver.
DR   ExpressionAtlas; E9PG08; baseline and differential.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR025764; Cystatin_Fetuin_B.
DR   Pfam; PF00031; Cystatin; 1.
DR   SMART; SM00043; CY; 1.
DR   PROSITE; PS51530; CYSTATIN_FETUIN_B; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PG08,
KW   ECO:0000213|PeptideAtlas:E9PG08};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    317       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245178.
FT   DOMAIN       25     72       Cystatin fetuin-B-type.
FT                                {ECO:0000259|PROSITE:PS51530}.
FT   DOMAIN       84    190       Cystatin fetuin-B-type.
FT                                {ECO:0000259|PROSITE:PS51530}.
SQ   SEQUENCE   317 AA;  34556 MW;  3EBF11155F9AE26F CRC64;
     MGLLLPLALC ILVLCCGAMS PPQLALNPSA LLSRGCNDSD VLAVAGFALR DINKDRKDGY
     VLRLNRVNDA QEYRRAISKK KIYMTCPDCP SSIPTDSSNH QVLEAATESL AKYNNENTSK
     QYSLFKVTRA SSQWVVGPSY FVEYLIKESP CTKSQASSCS LQSSDSVPVG LCKGSLTRTH
     WEKFVSVTCD FFESQAPATG SENSAVNQKP TNLPKVEESQ QKNTPPTDSP SKAGPRGSVQ
     YLPDLDDKNS QEKGPQEAFP VHLDLTTNPQ GETLDISFLF LEPMEEKLVV LPFPKEKART
     AECPGPAQNA SPLVLPP
//