ID   E9PFZ2_HUMAN            Unreviewed;       946 AA.
AC   E9PFZ2;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 58.
DE   SubName: Full=Ceruloplasmin {ECO:0000313|Ensembl:ENSP00000418773};
GN   Name=CP {ECO:0000313|Ensembl:ENSP00000418773};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000418773, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000418773, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000418773}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SIMILARITY: Belongs to the multicopper oxidase family.
CC       {ECO:0000256|SAAS:SAAS00534212}.
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DR   EMBL; AC093001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC131209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PFZ2; -.
DR   jPOST; E9PFZ2; -.
DR   MaxQB; E9PFZ2; -.
DR   PeptideAtlas; E9PFZ2; -.
DR   PRIDE; E9PFZ2; -.
DR   Ensembl; ENST00000481169; ENSP00000418773; ENSG00000047457.
DR   UCSC; uc062owf.1; human.
DR   EuPathDB; HostDB:ENSG00000047457.13; -.
DR   HGNC; HGNC:2295; CP.
DR   OpenTargets; ENSG00000047457; -.
DR   eggNOG; KOG1263; Eukaryota.
DR   eggNOG; COG2132; LUCA.
DR   GeneTree; ENSGT00940000155866; -.
DR   ChiTaRS; CP; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000047457; Expressed in 185 organ(s), highest expression level in liver.
DR   ExpressionAtlas; E9PFZ2; baseline and differential.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004322; F:ferroxidase activity; IEA:InterPro.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro.
DR   GO; GO:0006825; P:copper ion transport; IEA:InterPro.
DR   Gene3D; 2.60.40.420; -; 6.
DR   InterPro; IPR027150; CP.
DR   InterPro; IPR001117; Cu-oxidase.
DR   InterPro; IPR011707; Cu-oxidase_3.
DR   InterPro; IPR033138; Cu_oxidase_CS.
DR   InterPro; IPR008972; Cupredoxin.
DR   PANTHER; PTHR44048:SF5; PTHR44048:SF5; 2.
DR   Pfam; PF00394; Cu-oxidase; 1.
DR   Pfam; PF07732; Cu-oxidase_3; 2.
DR   SUPFAM; SSF49503; SSF49503; 6.
DR   PROSITE; PS00079; MULTICOPPER_OXIDASE1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Copper {ECO:0000256|SAAS:SAAS00524507};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00524516};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PFZ2,
KW   ECO:0000213|PeptideAtlas:E9PFZ2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    946       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242837.
FT   DOMAIN       92    202       Plastocyanin-like.
FT                                {ECO:0000259|Pfam:PF07732}.
FT   DOMAIN      223    357       Plastocyanin-like.
FT                                {ECO:0000259|Pfam:PF00394}.
FT   DOMAIN      736    828       Plastocyanin-like.
FT                                {ECO:0000259|Pfam:PF07732}.
SQ   SEQUENCE   946 AA;  108820 MW;  6CFBF15BA0524E75 CRC64;
     MKILILGIFL FLCSTPAWAK EKHYYIGIIE TTWDYASDHG EKKLISVDTE HSNIYLQNGP
     DRIGRLYKKA LYLQYTDETF RTTIEKPVWL GFLGPIIKAE TGDKVYVHLK NLASRPYTFH
     SHGITYYKEH EGAIYPDNTT DFQRADDKVY PGEQYTYMLL ATEEQSPGEG DGNCVTRIYH
     SHIDAPKDIA SGLIGPLIIC KKDSLDKEKE KHIDREFVVM FSVVDENFSW YLEDNIKTYC
     SEPEKVDKDN EDFQESNRMY SVNGYTFGSL PGLSMCAEDR VKWYLFGMGN EVDVHAAFFH
     GQALTNKNYR IDTINLFPAT LFDAYMVAQN PGEWMLSCQN LNHLKAGLQA FFQVQECNKS
     SSKDNIRGKH VRHYYIAAEE IIWNYAPSGI DIFTKENLTA PGSDSAVFFE QGTTRIGGSY
     KKLVYREYTD ASFTNRKERG PEEEHLGILG PVIWAEVGDT IRVTFHNKGA YPLSIEPIGV
     RFNKNNEGTY YSPNYNPQSR SVPPSASHVA PTETFTYEWT VPKEVGPTNA DPVCLAKMYY
     SAVEPTKDIF TGLIGPMKIC KKGSLHANGR QKDVDKEFYL FPTVFDENES LLLEDNIRMF
     TTAPDQVDKE DEDFQESNKM HWTFNVECLT TDHYTGGMKQ KYTVNQCRRQ SEDSTFYLGE
     RTYYIAAVEV EWDYSPQREW EKELHHLQEQ NVSNAFLDKG EFYIGSKYKK VVYRQYTDST
     FRVPVERKAE EEHLGILGPQ LHADVGDKVK IIFKNMATRP YSIHAHGVQT ESSTVTPTLP
     GETLTYVWKI PERSGAGTED SACIPWAYYS TVDQVKDLYS GLIGPLIVCR RPYLKVFNPR
     RKLEFALLFL VFDENESWYL DDNIKTYSDH PEKVNKDDEE FIESNKMHAI NGRMFGNLQG
     LTMHVGDEVN WYLMGMGNEI DLHTVHFHGH SFQYKHLLRL TGEYGM
//