ID   E9PFX0_HUMAN            Unreviewed;       401 AA.
AC   E9PFX0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 70.
DE   SubName: Full=Hepatitis A virus cellular receptor 1 {ECO:0000313|Ensembl:ENSP00000428524};
GN   Name=HAVCR1 {ECO:0000313|Ensembl:ENSP00000428524};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428524, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428524, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000213|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [3] {ECO:0000313|Ensembl:ENSP00000428524}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSP00000487363}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
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DR   EMBL; AC026777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001295085.1; NM_001308156.1.
DR   UniGene; Hs.129711; -.
DR   SMR; E9PFX0; -.
DR   MaxQB; E9PFX0; -.
DR   PRIDE; E9PFX0; -.
DR   Ensembl; ENST00000522693; ENSP00000428524; ENSG00000113249.
DR   Ensembl; ENST00000625904; ENSP00000487363; ENSG00000113249.
DR   GeneID; 26762; -.
DR   UCSC; uc011ddl.2; human.
DR   CTD; 26762; -.
DR   EuPathDB; HostDB:ENSG00000113249.12; -.
DR   HGNC; HGNC:17866; HAVCR1.
DR   OpenTargets; ENSG00000113249; -.
DR   GeneTree; ENSGT00940000159345; -.
DR   OMA; LWHNNQT; -.
DR   OrthoDB; 1147868at2759; -.
DR   ChiTaRS; HAVCR1; human.
DR   GenomeRNAi; 26762; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000113249; Expressed in 77 organ(s), highest expression level in adult mammalian kidney.
DR   ExpressionAtlas; E9PFX0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00653601};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PFX0,
KW   ECO:0000213|PeptideAtlas:E9PFX0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    401       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014571006.
FT   TRANSMEM    296    324       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        3    121       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   401 AA;  44002 MW;  836163773CFCDB0B CRC64;
     MHPQVVILSL ILHLADSVAG SVKVGGEAGP SVTLPCHYSG AVTSMCWNRG SCSLFTCQNG
     IVWTNGTHVT YRKDTRYKLL GDLSRRDVSL TIENTAVSDS GVYCCRVEHR GWFNDMKITV
     SLEIVPPKVT TTPIVTTVPT VTTVRTSTTV PTTTTVPMTT VPTTTVPTTM SIPTTTTVLT
     TMTVSTTTSV PTTTSIPTTT SVPVTTTVST FVPPMPLPRQ NHEPVATSPS SPQPAETHPT
     TLQGAIRREP TSSPLYSYTT DGNDTVTESS DGLWNNNQTQ LFLEHSLLTA NTTKGIYAGV
     CISVLVLLAL LGVIIAKMFH LAAFKLKLCK MQLKRKSKQK TISTLRIVFM PRTKTQWCSL
     RVYAHECRRL NRHQHIRRLL DPKTIFLFQF HLAFQHVSDT G
//