ID   E9PFW2_HUMAN            Unreviewed;       822 AA.
AC   E9PFW2;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 58.
DE   SubName: Full=Beta-mannosidase {ECO:0000313|Ensembl:ENSP00000427322};
GN   Name=MANBA {ECO:0000313|Ensembl:ENSP00000427322};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000427322, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000427322, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000427322}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC018797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF213884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF454940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PFW2; -.
DR   jPOST; E9PFW2; -.
DR   MaxQB; E9PFW2; -.
DR   PeptideAtlas; E9PFW2; -.
DR   PRIDE; E9PFW2; -.
DR   Ensembl; ENST00000505239; ENSP00000427322; ENSG00000109323.
DR   UCSC; uc011ces.3; human.
DR   EuPathDB; HostDB:ENSG00000109323.8; -.
DR   HGNC; HGNC:6831; MANBA.
DR   OpenTargets; ENSG00000109323; -.
DR   eggNOG; KOG2230; Eukaryota.
DR   eggNOG; COG3250; LUCA.
DR   GeneTree; ENSGT00390000001670; -.
DR   ChiTaRS; MANBA; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000109323; Expressed in 208 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; E9PFW2; baseline and differential.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; -; 2.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR006103; Glyco_hydro_2_cat.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF02836; Glyco_hydro_2_C; 1.
DR   SUPFAM; SSF49303; SSF49303; 3.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E9PFW2,
KW   ECO:0000213|MaxQB:E9PFW2, ECO:0000213|PeptideAtlas:E9PFW2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    822       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003245016.
FT   DOMAIN      286    504       Glyco_hydro_2_C.
FT                                {ECO:0000259|Pfam:PF02836}.
SQ   SEQUENCE   822 AA;  94412 MW;  0C2BA7504C91EA13 CRC64;
     MRLHLLLLLA LCGAGTTAAE LSYSLRGNWS ICNGNGSLEL PGAVPGCVHS ALFQQGLIQD
     SYYRFNDLNY RWVSLDNWTY SKEFKIPFEI SKWQKVNLIL EGVDTVSKIL FNEVTIGETD
     NMFNRYEQCS FSWDWGPSFP TQGIWKDVRI EAYNICHLNY FTFSPIYDKS AQEWNLEIES
     TFDVVSSKPV GGQVIVAIPK LQTQQTYSIE LQPGKRIVEL FVNISKNITV ETWWPHGHGN
     QTGYNMTVLF ELDGGLNIEK SAKVYFRTVE LIEEPIKGSP GLSFYFKING FPIFLKGSNW
     IPADSFQDRV TSELLRLLLQ SVVDANMNTL RVWGGGIYEQ DEFYELCDEL GIMVWQDFMF
     ACALYPTDQG FLDSVTAEVA YQIKRLKSHP SIIIWSGNNE NEEALMMNWY HISFTDRPIY
     IKDYVTLYVK NIRELVLAGD KSRPFITSSP TNGAETVAEA WVSQNPNSNY FGDVHFYDYI
     SDCWNWKVFP KARFASEYGY QSWPSFSTLE KVSSTEDWSF NSKFSLHRQH HEGGNKQMLY
     QAGLHFKLPQ STDPLRTFKD TIYLTQVMQA QCVKTETEFY RRSRSEIVDQ QGHTMGALYW
     QLNDIWQAPS WASLEYGGKW KMLHYFAQNF FAPLLPVGFE NENTFYIYGV SDLHSDYSMT
     LSVRVHTWSS LEPVCSRVTE RFVMKGGEAV CLYEEPVSEL LRRCGNCTRE SCVVSFYLSA
     DHELLSPTNY HFLSSPKEAV GLCKAQITAI ISQQGDIFVF DLETSAVAPF VWLDVGSIPG
     RFSDNGFLMT EKTRTILFYP WEPTSKNELE QSFHVTSLTD IY
//